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. 2025 Jan 20;14(1):piae121.
doi: 10.1093/jpids/piae121.

Protection From COVID-19 Vaccination and Prior SARS-CoV-2 Infection Among Children Aged 6 Months-4 Years, United States, September 2022-April 2023

Leora R Feldstein  1 , Jasmine Ruffin  1 , Ryan Wiegand  1 , Lauren Grant  1 , Tara M Babu  2 , Melissa Briggs-Hagen  1 , Jefferey L Burgess  3 , Alberto J Caban-Martinez  4 , Helen Y Chu  2 , Katherine D Ellingson  3 , Janet A Englund  5 , Kurt T Hegmann  6 , Zuha Jeddy  7 , Jennifer Kuntz  8 , Adam S Lauring  9 , Karen Lutrick  3 , Emily T Martin  10 , Clare Mathenge  11 , Jennifer Meece  12 , Claire M Midgley  1 , Arnold S Monto  10 , Allison L Naleway  8 , Gabriella Newes-Adeyi  7 , Leah Odame-Bamfo  11 , Lauren E W Olsho  7 , Andrew L Phillips  6 , Ramona P Rai  7 , Sharon Saydah  1 , Ning Smith  8 , Harmony Tyner  13 , Molly Vaughan  7 , Ana A Weil  2 , Sarang K Yoon  6 , Amadea Britton  1 , Manjusha Gaglani  11   14
Affiliations

Protection From COVID-19 Vaccination and Prior SARS-CoV-2 Infection Among Children Aged 6 Months-4 Years, United States, September 2022-April 2023

Leora R Feldstein et al. J Pediatric Infect Dis Soc. .

Abstract

To understand how coronavirus disease 2019 vaccines impact infection risk in children <5 years, we assessed risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection from September 2022 to April 2023 in 3 cohort studies. There was no difference in risk by vaccination status. While vaccines reduce severe disease, they may not reduce SARS-CoV-2 infections in naïve young children.

Keywords: COVID-19; SARS-CoV-2; children; prior infection; vaccination.

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