doi: 10.1016/0090-6980(79)90093-5.
Measurement of 6-oxo-PGF1 alpha in human plasma using gas chromatography-mass spectrometry
- PMID: 396578
- DOI: 10.1016/0090-6980(79)90093-5
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Measurement of 6-oxo-PGF1 alpha in human plasma using gas chromatography-mass spectrometry
Prostaglandins.
1979 Nov.
Abstract
The plasma concentration of the prostacyclin (PGI2) hydration product 6-oxo-PGF1 alpha has been assayed by stable isotope dilution GC-MS in six normal volunteers infused with increasing doses of PGI2 intravenously. The predosing levels of 6-oxo-PGF1 alpha ranged between 114 and 266 pg/ml. Infusion of PGI2 increased 6-oxo-PGF1 alpha concentration in plasma but the increments were lower than expected suggesting less conversion of the PGI2 to 6-oxo-PGF1 alpha at high infusion rates.
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