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. 1979 Nov;18(5):731-6.
doi: 10.1016/0090-6980(79)90093-5.

Measurement of 6-oxo-PGF1 alpha in human plasma using gas chromatography-mass spectrometry

C N Hensby, G A Fitzgerald, L A Friedman, P J Lewis, C T Dollery

Measurement of 6-oxo-PGF1 alpha in human plasma using gas chromatography-mass spectrometry

C N Hensby et al. Prostaglandins. 1979 Nov.

Abstract

The plasma concentration of the prostacyclin (PGI2) hydration product 6-oxo-PGF1 alpha has been assayed by stable isotope dilution GC-MS in six normal volunteers infused with increasing doses of PGI2 intravenously. The predosing levels of 6-oxo-PGF1 alpha ranged between 114 and 266 pg/ml. Infusion of PGI2 increased 6-oxo-PGF1 alpha concentration in plasma but the increments were lower than expected suggesting less conversion of the PGI2 to 6-oxo-PGF1 alpha at high infusion rates.

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