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. 2024 Nov 10;16(11):e73368.
doi: 10.7759/cureus.73368. eCollection 2024 Nov.

Outcomes of A2/A2B to B Deceased Donor Kidney Transplantation: A Retrospective Study

Mia A Jose  1 , Ketan Tamirisa  2 , Srichandra Pallerla  3 , Debra Meeks  4 , Anna Curtis  4 , Kathryn Lozano  4 , Jessica Morton  4 , Machaiah Madhrira  5 , Ashraf I Reyad  6 , Sridhar R Allam  5   7
Affiliations

Outcomes of A2/A2B to B Deceased Donor Kidney Transplantation: A Retrospective Study

Mia A Jose et al. Cureus. .

Abstract

Background A2/A2B to B kidney transplantation has the potential to increase transplant access for traditionally disadvantaged blood group B minority candidates. Despite prior reports of positive post-transplant safety and clinical success, A2/A2B to B kidney transplantation remains underutilized in the United States. This study aims to investigate the post-transplant outcomes of A2/A2B to B kidney transplants performed at our center. Methods A retrospective study of all A2/A2B to B deceased donor kidney transplants (DDKTs) at our center from 2017 through 2023 was performed. Recipient and donor demographics, recipient medical history, time to transplant from listing, and post-transplant clinical outcomes were assessed, including one-year graft and patient survival. Results Of the 54 A2/A2B to B DDKTs performed during this period, 36 recipients were male, and 18 were female. The mean recipient age was 53.2 years. There were 22 (40.7%) African American recipients, 12 (22.2%) Hispanic recipients, 11 (20.3%) Caucasian recipients, eight (14.8%) Asian recipients, and one (1.8%) recipient of "other" race. The mean estimated post-transplant survival score was 46.5%. The mean donor age was 40.2 years, and the mean kidney donor profile index score was 44%. The mean time from waitlisting to transplant was 216 days. Delayed graft function was observed in five (9.2%) patients. Three (5.5%) patients had biopsy-proven acute rejection in the first year after transplant. The mean serum creatinine at one-year post-transplant was 1.4 mg/dL. At one-year post-transplant, graft survival was 96.2%, and patient survival was 98.1%. Conclusions Our study demonstrated excellent one-year post-transplant graft and patient survival rates with A2/A2B to B DDKT, with minority candidates predominantly benefiting from this.

Keywords: a2/a2b to b kidney transplantation; blood group b candidates; clinical success kidney transplants; minority candidates; post-transplant outcomes; transplant access.

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Conflict of interest statement

Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Medical City Healthcare Institutional Review Board issued approval MCOR-01. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

References

    1. Factors affecting the waiting time of cadaveric kidney transplant candidates in the United States. Sanfilippo FP, Vaughn WK, Peters TG, et al. https://jamanetwork.com/journals/jama/article-abstract/394408. JAMA. 1992;267:247–252. - PubMed
    1. A2/A2 B to B renal transplantation: past, present, and future directions. Bryan CF, Cherikh WS, Sesok-Pizzini DA. Am J Transplant. 2016;16:11–20. - PubMed
    1. Renal transplantation in Black Americans. Young CJ, Gaston RS. N Engl J Med. 2000;343:1545–1552. - PubMed
    1. Disparities in the utilization of live donor renal transplantation. Gore JL, Danovitch GM, Litwin MS, Pham PT, Singer JS. Am J Transplant. 2009;9:1124–1133. - PubMed
    1. Blood group A and B antigen expression in human kidneys correlated to A1/A2/B, Lewis, and secretor status. Breimer ME, Mölne J, Nordén G, Rydberg L, Thiel G, Svalander CT. Transplantation. 2006;82:479–485. - PubMed

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