Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Nov 14;6(12):547-554.
doi: 10.1253/circrep.CR-24-0105. eCollection 2024 Dec 10.

Association Between Amount of Physical Activity and Clinical Outcomes After Treatment for Cardiovascular Disease in Cancer Survivors

Kohei Nozaki  1 , Nobuaki Hamazaki  1 , Kentaro Kamiya  2   3 , Kensuke Ueno  3 , Takashi Miki  3 , Yuta Nanri  1 , Ken Ogura  3 , Shota Uchida  3 , Emi Maekawa  4 , Takeru Nabeta  4 , Yuichiro Iida  4 , Minako Yamaoka-Tojo  2   3 , Atsuhiko Matsunaga  2   3 , Jiichiro Sasaki  5 , Junya Ako  4
Affiliations

Association Between Amount of Physical Activity and Clinical Outcomes After Treatment for Cardiovascular Disease in Cancer Survivors

Kohei Nozaki et al. Circ Rep. .

Abstract

Background: The present study aimed to investigate the association between physical activity before the incidence of cardiovascular disease (CVD) and clinical outcomes in cancer survivors.

Methods and results: We analyzed 904 cancer survivors (median age [interquartile range] 75 [68-80] years; 297 [32.9%] patients were female) who required hospitalization for treatment of CVD. The amount of physical activity 1 month before the admission was assessed using the 3-question (3Q) assessment tool, and categorized as minimal, low, adequate, and high according to physical activity level. The primary outcome was the composite events of all-cause death and/or rehospitalization for CVD up to 1 year after discharge. The total amount of physical activity was identified in 544 (60.2%) patients in the minimal group, 95 (10.5%) in the low group, 253 (28.0%) in the adequate group, and 12 (1.3%) in the high group. A total of 686 (75.9%) patients completed follow up, with 252 (27.9%) composite events occurring. Even after adjustment for various confounders, higher physical activity was significantly associated with a lower composite event rate (adjusted hazard ratio [95% confidence interval] 0.859 [0.833-0.900]).

Conclusions: High physical activity in cancer survivors was associated with a lower composite event rate after treatment for CVD. Assessment of prehospital physical activity using the 3Q score may be useful in their risk stratification.

Keywords: Cancer survivor; Cardio-oncology; Cardiovascular disease; Clinical outcome; Physical activity.

PubMed Disclaimer

Conflict of interest statement

K.K., J.A. are members of Circulation Reports’ Editorial Team. All authors declare that there is no conflict of interest.

Figures

Figure 1.
Figure 1.
Flowchart of patient selection. CVD, cardiovascular disease.
Figure 2.
Figure 2.
Kapan-Meier survival curve for composite events according to physical activity levels. A higher physical activity was associated with a lower rate of composite events.
Figure 3.
Figure 3.
Results of the subgroup analysis for the Cox proportional hazard model. High physical activity was consistently associated with a lower rate of composite events. ADHF, acute decompensated heart failure; CVD, cardiovascular disease.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Siegel RL, Miller KD, Wagle NS, Jemal A.. Cancer statistics, 2023. CA Cancer J Clin 2023; 73: 17–48, doi:10.3322/caac.21763. - PubMed
    1. Nguyen PT, Hori M, Matsuda T, Katanoda K.. Cancer prevalence projections in Japan and decomposition analysis of changes in cancer burden, 2020–2050: A statistical modeling study. Cancer Epidemiol Biomarkers Prev 2023; 32: 1756–1770, doi:10.1158/1055-9965.EPI-23-0754. - PMC - PubMed
    1. Strongman H, Gadd S, Matthews AA, Mansfield KE, Stanway S, Lyon AR, et al.. Does cardiovascular mortality overtake cancer mortality during cancer survivorship?: An English retrospective cohort study. JACC CardioOncol 2022; 4: 113–123, doi:10.1016/j.jaccao.2022.01.102. - PMC - PubMed
    1. Florido R, Daya NR, Ndumele CE, Koton S, Russell SD, Prizment A, et al.. Cardiovascular disease risk among cancer survivors: The Atherosclerosis Risk In Communities (ARIC) Study. J Am Coll Cardiol 2022; 80: 22–32, doi:10.1016/j.jacc.2022.04.042. - PMC - PubMed
    1. Cancer survivors have an increased risk of cardiovascular disease. Cancer 2022; 128: 3756, doi:10.1002/cncr.34501. - PubMed