Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Nov 27;20(2):1047-1052.
doi: 10.1016/j.radcr.2024.10.141. eCollection 2025 Feb.

Retrograde endovascular intervention treating chronic limb threatening ischemia: A case report

Affiliations
Case Reports

Retrograde endovascular intervention treating chronic limb threatening ischemia: A case report

Tran Minh Bao Luan et al. Radiol Case Rep. .

Abstract

The retrograde approach is an adjunctive technique for endovascular intervention, particularly in the treatment of lower extremity arterial disease with multilevel vascular lesions. Combined with revascularization therapy, wound care plays a pivotal role in the management of patients with chronic limb-threatening ischemia. We present a case of chronic limb-threatening ischemia, with complex multilevel vascular lesions successfully treated using a retrograde endovascular approach alongside aggressive wound care management. Postintervention, the patient demonstrated a notable increase in ankle-brachial index from 0 to 1, along with accelerated wound healing and preservation of limb function. This case highlights the efficacy of the retrograde approach in restoring perfusion, particularly in chronic total occlusions, and emphasizes the importance of combining revascularization and wound care for optimal chronic limb-threatening ischemia management.

Keywords: Chronic limb-threatening ischemia; Endovascular intervention; Peripheral vascular disease; Retrograde approach; Wound care.

PubMed Disclaimer

Figures

Fig 1
Fig. 1
(A) Right foot ulcer with WIfI (Wound, Ischemia, and foot Infection) stage 4 (W3 I3 fI 3). (B) Left foot ulcer with WIfI (Wound, Ischemia, and foot Infection) stage 3 (W1 I3 fI 3). (C) Computed tomography angiography of the lower extremity arteries.
Fig 2
Fig. 2
Lesions of the arterial system of the lower extremities on both sides, GLASS grade 3 for the FP level with moderate stenosis of the bilateral CIA, occlusion of the left EIA, occlusion of the bilateral CFA and SFA. Guiding the need for retrograde access.
Fig 3
Fig. 3
(A) Right PA access. (B) Angiography showing the patency of the right FP artery following intervention.
Fig 4
Fig. 4
(A) Left PA access. (B) Angiography showing the patency of the left SFA following intervention. (C) Angiography showing the patency of the left EIA, CFA following intervention.
Fig 5
Fig. 5
(A) Ulcer on the right foot postintervention at 1 month. (B) Right foot at 3 months. (C) Right foot at 1 year. (D) Ulcer on the left foot postintervention at 1 month. (E) Left foot at 3 months.

References

    1. Kim TI, Mena C, Sumpio BE. The role of lower extremity amputation in chronic limb-threatening ischemia. Int J Angiol. 2020;29(3):149–155. - PMC - PubMed
    1. Wijnand JGJ, Zarkowsky D, Wu B, van Haelst STW, Vonken EPA, Sorrentino TA, et al. The Global Limb Anatomic Staging System (GLASS) for CLTI: improving inter-observer agreement. J Clin Med. 2021;10(16):3454. - PMC - PubMed
    1. Cha JJ, Kim JY, Kim H, Ko YG, Choi D, Lee JH, et al. Long-term clinical outcomes and prognostic factors after endovascular treatment in patients with chronic limb threatening ischemia. Korean Circ J. 2022;52(6):429–440. - PMC - PubMed
    1. Almasri J, Adusumalli J, Asi N, Lakis S, Alsawas M, Prokop LJ, et al. A systematic review and meta-analysis of revascularization outcomes of infrainguinal chronic limb-threatening ischemia. Eur J Vasc Endovasc Surg. 2019;58(1S):S110–S1S9. - PubMed
    1. Aboyans V, Ricco J-B, Bartelink M-L, Björck M, Brodmann M, Cohner T, et al. 2017 ESC guidelines on the diagnosis and treatment of peripheral arterial diseases, in collaboration with the European Society for Vascular Surgery (ESVS) Kardiologia Polska (Polish Heart Journal) 2017;75(11):1065–1160. - PubMed

Publication types

LinkOut - more resources