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. 2024 Dec 6:16:1949-1958.
doi: 10.2147/NSS.S482592. eCollection 2024.

Association Between Sleep Quality and Cirrhotic Cardiomyopathy: A Prospective Case-Control Study

Fei Liu #  1 , Tianqing Cao #  1 , Yacong Liu  1 , Dian Huang  2 , Jingxin Zhang  3
Affiliations

Association Between Sleep Quality and Cirrhotic Cardiomyopathy: A Prospective Case-Control Study

Fei Liu et al. Nat Sci Sleep. .

Abstract

Objective: The main purpose of this study is to evaluate the changes in sleep quality among patients with cirrhotic cardiomyopathy (CCM).

Methods: The study included liver cirrhosis patients aged 18-75 from Northern Jiangsu People's Hospital Affiliated to Yangzhou University and collected their clinical examination results to assess the clinical characteristics and related risk factors of patients with CCM.

Results: The study found that the onset of CCM was not related to the etiology of inducing cirrhosis. Pittsburgh Sleep Quality Index (PSQI) score (odds ratio (OR) = 13.476, 95% confidence interval (CI) = 1.514-119.923, P = 0.020), absolute GLS (OR = 0.328, 95% CI = 0.210-0.510, P < 0.001), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) (OR = 1.050, 95% CI = 1.025-1.076, P < 0.001) were identified as independent risk factors for inducing CCM.

Conclusion: In patients with CCM, a decrease in sleep quality often occurs. When cirrhotic patients also have poor sleep quality, along with a decrease in absolute Global Left Ventricular Strain (GLS) levels and an increase in NT-proBNP levels, these factors may pose a higher risk for CCM development. However, further validation of these research findings is required in larger sample sizes.

Keywords: cardiomyopathy; cirrhotic cardiomyopathy; liver cirrhosis; sleep quality.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Patient enrollment flowchart.
Figure 2
Figure 2
Correlation between global PSQI score and (A) NT-proBNP, (B) Absolute GLS.
Figure 3
Figure 3
Comparison of amphiregulin with other indicators, such as PSQI score, absolute GLS and NT -proBNP for the diagnosis of CCM by areas under the receiver operating curves (AUROCs).
See this image and copyright information in PMC

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