Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2024 Nov 26:37:14032.
doi: 10.3389/ti.2024.14032. eCollection 2024.

Shedding Light on Microvascular Inflammation: Understanding Outcomes, But What Sparks the Flame?

Louise Benning  1 , Oriol Bestard  2
Affiliations
Comment

Shedding Light on Microvascular Inflammation: Understanding Outcomes, But What Sparks the Flame?

Louise Benning et al. Transpl Int. .
No abstract available

Keywords: antibody-mediated rejection; biomarkers; kidney transplantation; microvascular inflammation; targeted therapies.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Towards personalizing transplant care – from rejection phenotypes to targeted therapies. This summary figure illustrates the essential steps toward personalized transplant care, including the classification of rejection phenotypes through conventional histopathology and molecular tools, understanding associated outcomes, exploring underlying immunological mechanisms, identifying disease-specific biomarkers, and ultimately developing targeted therapies based on these insights.
See this image and copyright information in PMC

Comment on

  • Microvascular Inflammation of Kidney Allografts and Clinical Outcomes.
    Sablik M, Sannier A, Raynaud M, Goutaudier V, Divard G, Astor BC, Weng P, Smith J, Garro R, Warady BA, Zahr RS, Twombley K, Dharnidharka VR, Dandamudi RS, Fila M, Huang E, Sellier-Leclerc AL, Tönshoff B, Rabant M, Verine J, Del Bello A, Berney T, Boyer O, Catar RA, Danger R, Giral M, Yoo D, Girardin FR, Alsadi A, Gourraud PA, Morelon E, Le Quintrec M, Try M, Villard J, Zhong W, Bestard O, Budde K, Chauveau B, Couzi L, Brouard S, Hogan J, Legendre C, Anglicheau D, Aubert O, Kamar N, Lefaucheur C, Loupy A. Sablik M, et al. N Engl J Med. 2025 Feb 20;392(8):763-776. doi: 10.1056/NEJMoa2408835. Epub 2024 Oct 24. N Engl J Med. 2025. PMID: 39450752

References

    1. Sablik M, Sannier A, Raynaud M, Goutaudier V, Divard G, Astor BC, et al. Microvascular Inflammation of Kidney Allografts and Clinical Outcomes. N Engl J Med (2024). 10.1056/nejmoa2408835 - DOI - PubMed
    1. Naesens M, Roufosse C, Haas M, Lefaucheur C, Mannon RB, Adam BA, et al. The Banff 2022 Kidney Meeting Report: Reappraisal of Microvascular Inflammation and the Role of Biopsy-Based Transcript Diagnostics. Am J Transpl (2024) 24:338–49. 10.1016/j.ajt.2023.10.016 - DOI - PubMed
    1. Loupy A, Haas M, Roufosse C, Naesens M, Adam B, Afrouzian M, et al. The Banff 2019 Kidney Meeting Report (I): Updates on and Clarification of Criteria for T Cell– and Antibody‐Mediated Rejection. Am J Transpl (2020) 20:2318–31. 10.1111/ajt.15898 - DOI - PMC - PubMed
    1. Senev A, Coemans M, Lerut E, Sandt VV, Daniëls L, Kuypers D, et al. Histological Picture of Antibody-Mediated Rejection Without Donor-Specific Anti-HLA Antibodies: Clinical Presentation and Implications for Outcome. Am J Transpl (2019) 19:763–80. 10.1111/ajt.15074 - DOI - PubMed
    1. Callemeyn J, Ameye H, Lerut E, Senev A, Coemans M, Loon EV, et al. Revisiting the Changes in the Banff Classification for Antibody-Mediated Rejection After Kidney Transplantation. Am J Transpl (2021) 21:2413–23. 10.1111/ajt.16474 - DOI - PubMed

LinkOut - more resources