A Comprehensive Review of Nanostructured Lipid Carriers: Innovations and Applications in Breast Cancer Treatment

Abstract

Nanostructured Lipid Carriers (NLCs) represent a promising advancement in the treatment of breast cancer, addressing the significant challenges posed by conventional chemotherapy, such as poor drug solubility, short half-lives, and high toxicity. This review delves into the potential of NLCs to overcome these limitations, highlighting their unique structure comprising a solid and lipid liquid core stabilized by surfactants. By examining diverse lipid blends used in the preparation of NLCs, the article emphasizes their suitability for targeted drug delivery. Various facets of NLC configuration, categorization, composition, and formulation approaches are systematically explored to provide a comprehensive understanding of their attributes. The findings reveal that NLCs possess a high capacity for lipophilic drugs and offer advantages over traditional lipid-based nanocarriers. The review underscores the pivotal role of NLCs in enhancing drug delivery efficiency for breast cancer therapy while minimizing systemic toxicity. Conclusively, this review positions NLCs as a key player in the evolution of drug delivery systems for breast cancer treatment, providing a detailed outlook on their transformative potential and contributing to a nuanced understanding of their significance in advancing the field of breast cancer treatment.

Keywords: Antineoplastic agents; breast cancer treatment; chemotherapy; drug delivery systems; nanostructured lipid carriers; targeted drug delivery..