Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2024 Dec 10;57(12):2712-2714.
doi: 10.1016/j.immuni.2024.11.011.

Hidradenitis suppurativa: TLSs take the center stage

Cody Elkins  1 , Chaoran Li  2
Affiliations
Comment

Hidradenitis suppurativa: TLSs take the center stage

Cody Elkins et al. Immunity. .

Abstract

Hidradenitis suppurativa (HS) is a severe chronic inflammatory skin disease with limited response to therapy. In this issue of Immunity, Yu et al.1 identify skin tertiary lymphoid structures (TLSs) as primary sites for lymphocyte clonal expansion and autoantibody production, driving disease progression, and provide insight into how formation and maintenance of TLS impact therapeutic outcomes.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

References

    1. Sabat R, Jemec GBE, Matusiak L, Kimball AB, Prens E, and Wolk K (2020). Hidradenitis suppurativa. Nat Rev Dis Primers 6, 18. 10.1038/s41572-020-0149-1. - DOI - PubMed
    1. Lowe MM, Naik HB, Clancy S, Pauli M, Smith KM, Bi Y, Dunstan R, Gudjonsson JE, Paul M, Harris H, et al. (2020). Immunopathogenesis of hidradenitis suppurativa and response to anti-TNF-alpha therapy. JCI Insight 5. 10.1172/jci.insight.139932. - DOI - PMC - PubMed
    1. Kimball AB, Okun MM, Williams DA, Gottlieb AB, Papp KA, Zouboulis CC, Armstrong AW, Kerdel F, Gold MH, Forman SB, et al. (2016). Two Phase 3 Trials of Adalimumab for Hidradenitis Suppurativa. N Engl J Med 375, 422–434. 10.1056/NEJMoa1504370. - DOI - PubMed
    1. Sato Y, Silina K, van den Broek M, Hirahara K, and Yanagita M (2023). The roles of tertiary lymphoid structures in chronic diseases. Nat Rev Nephrol 19, 525–537. 10.1038/s41581-023-00706-z. - DOI - PMC - PubMed
    1. Gudjonsson JE, Tsoi LC, Ma F, Billi AC, van Straalen KR, Vossen A, van der Zee HH, Harms PW, Wasikowski R, Yee CM, et al. (2020). Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis. JCI Insight 5. 10.1172/jci.insight.139930. - DOI - PMC - PubMed

MeSH terms

LinkOut - more resources