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Comment
. 2024 Dec 10;57(12):2715-2717.
doi: 10.1016/j.immuni.2024.11.012.

DC-T cell power couples in rheumatoid arthritis joints

Kazuhiko Higashioka  1 , Deepak A Rao  2
Affiliations
Comment

DC-T cell power couples in rheumatoid arthritis joints

Kazuhiko Higashioka et al. Immunity. .

Abstract

Rheumatoid arthritis (RA) is driven by antigen-specific T cell responses targeting the joints. MacDonald et al.1 define the range of dendritic cell (DC) populations within joints of RA patients and highlight specific iDC3 and DC2 populations enriched in inflamed RA synovium that promote T cell activation as well as tolerogenic AXL+ DC2s in healthy synovium that are lost in RA.

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Conflict of interest statement

Declaration of interests D.A.R. reports sponsored research from Janssen, Merck, and Bristol-Myers Squibb and reports personal fees from AstraZeneca, Pfizer, Merck, Amgen, Scipher Medicine, GlaxoSmithKline, and Bristol-Myers Squibb. He is co-inventor on a patent using T peripheral helper cells as a biomarker of autoimmune diseases and on a patent targeting Tph cells therapeutically.

Comment on

  • Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis.
    MacDonald L, Elmesmari A, Somma D, Frew J, Di Mario C, Madhu R, Paoletti A, Simakou T, Hardy OM, Tolusso B, Campobasso D, Perniola S, Gessi M, Gigante MR, Petricca L, Bruno D, Coletto LA, Benvenuto R, Isaacs JD, Filby A, McDonald D, Sim JPX, Jamieson N, Wei K, D'Agostino MA, Millar NL, Milling S, McSharry C, Gremese E, Affleck K, Baker KF, McInnes IB, Otto TD, Korsunsky I, Alivernini S, Kurowska-Stolarska M. MacDonald L, et al. Immunity. 2024 Dec 10;57(12):2843-2862.e12. doi: 10.1016/j.immuni.2024.11.004. Epub 2024 Nov 27. Immunity. 2024. PMID: 39609125

References

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