Review

. 2024 Dec;636(8042):322-331.

doi: 10.1038/s41586-024-08280-5. Epub 2024 Dec 11.

π-HuB: the proteomic navigator of the human body

Fuchu He^{1

2}, Ruedi Aebersold³, Mark S Baker⁴, Xiuwu Bian⁵, Xiaochen Bo⁶, Daniel W Chan⁷, Cheng Chang⁸, Luonan Chen⁹, Xiangmei Chen¹⁰, Yu-Ju Chen¹¹, Heping Cheng¹², Ben C Collins¹³, Fernando Corrales¹⁴, Jürgen Cox¹⁵, Weinan E^{16

17}, Jennifer E Van Eyk¹⁸, Jia Fan¹⁹, Pouya Faridi^{20

21}, Daniel Figeys²², George Fu Gao²³, Wen Gao^{24

25}, Zu-Hua Gao²⁶, Keisuke Goda^{27

28

29}, Wilson Wen Bin Goh³⁰, Dongfeng Gu³¹, Changjiang Guo³², Tiannan Guo^{33

34

35}, Yuezhong He³⁶, Albert J R Heck^{37

38}, Henning Hermjakob³⁹, Tony Hunter⁴⁰, Narayanan Gopalakrishna Iyer⁴¹, Ying Jiang⁸, Connie R Jimenez⁴², Lokesh Joshi⁴³, Neil L Kelleher⁴⁴, Ming Li^{45

46}, Yang Li⁸, Qingsong Lin⁴⁷, Cui Hua Liu⁴⁸, Fan Liu⁴⁹, Guang-Hui Liu⁵⁰, Yansheng Liu⁵¹, Zhihua Liu⁵², Teck Yew Low⁵³, Ben Lu⁵⁴, Matthias Mann⁵⁵, Anming Meng⁵⁶, Robert L Moritz⁵⁷, Edouard Nice⁵⁸, Guang Ning^{59

60

61}, Gilbert S Omenn⁶², Christopher M Overall^{63

64}, Giuseppe Palmisano⁶⁵, Yaojin Peng^{66

67

68}, Charles Pineau⁶⁹, Terence Chuen Wai Poon⁷⁰, Anthony W Purcell⁷¹, Jie Qiao⁷², Roger R Reddel⁷³, Phillip J Robinson⁷³, Paola Roncada⁷⁴, Chris Sander^{75

76}, Jiahao Sha⁷⁷, Erwei Song^{78

79}, Sanjeeva Srivastava⁸⁰, Aihua Sun⁸, Siu Kwan Sze⁸¹, Chao Tang⁸², Liujun Tang⁸, Ruijun Tian⁸³, Juan Antonio Vizcaíno³⁹, Chanjuan Wang⁸, Chen Wang^{84

85}, Xiaowen Wang⁸, Xinxing Wang³², Yan Wang⁸, Tobias Weiss⁸⁶, Mathias Wilhelm⁸⁷, Robert Winkler⁸⁸, Bernd Wollscheid⁸⁹, Limsoon Wong^{90

91}, Linhai Xie⁸, Wei Xie⁵⁶, Tao Xu^{92

93}, Tianhao Xu³⁶, Liying Yan⁷², Jing Yang⁹², Xiao Yang⁸, John Yates⁹⁴, Tao Yun⁹⁵, Qiwei Zhai⁹⁶, Bing Zhang^{97

98}, Hui Zhang⁹⁹, Lihua Zhang¹⁰⁰, Lingqiang Zhang⁸, Pingwen Zhang^{101

102}, Yukui Zhang¹⁰⁰, Yu Zi Zheng^{36

26}, Qing Zhong⁷³, Yunping Zhu⁸; π-HuB Consortium

Collaborators, Affiliations

Collaborators

π-HuB Consortium:
Daniel W Chan, Chris Soon Heng Tan, Weinan E, Jennifer E Van Eyk, Mingxia Gao, Qiang Gao, Yushun Gao, Xuejiang Guo, Jie He, Jun He, Qing-Yu He, Jinlin Hou, Canhua Huang, Chenxi Jia, Bernhard Kuster, Chaoying Li, Dong Li, Yan Li, Yanchang Li, Siqi Liu, Xiaonan Liu, Ya Liu, Zhongyang Liu, Haojie Lu, Yongzhan Nie, Mariko Okada, Guojun Qian, Hongqiang Qin, Yu Rao, Zihe Rao, Xianwen Ren, Yan Ren, Feng Shen, Lin Shen, Shicheng Su, Minjia Tan, Ben Zhong Tang, Sheng-Ce Tao, Jian Wang, Tong Wang, Liming Wei, Catherine C L Wong, Xiaoliang Sunney Xie, Li Xu, Ping Xu, Tao Xu, Huanming Yang, Jianjun Yang, Mingliang Ye, Wantao Ying, Xiaobo Yu, Yaxiang Yuan, Qingcun Zeng, Qimin Zhan, Xiaofei Zhang, Xu Zhang, Ying Zhang, Nan-Shan Zhong, Feng Zhou, Yi Zhu, Zemin Zhang

Affiliations

¹ State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China. hefc@bmi.ac.cn.
² International Academy of Phronesis Medicine (Guangdong), Guangdong, China. hefc@bmi.ac.cn.
³ Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland. aebersold@imsb.biol.ethz.ch.
⁴ Macquarie Medical School, Macquarie University, Sydney, New South Wales, Australia.
⁵ Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University) and Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China.
⁶ Institute of Health Service and Transfusion Medicine, Beijing, China.
⁷ Department of Pathology and The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.
⁸ State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
⁹ Key Laboratory of Systems Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.
¹⁰ Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, China.
¹¹ Institute of Chemistry, Academia Sinica, Taipei, China.
¹² National Biomedical Imaging Center, State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, College of Future Technology, Peking University, Beijing, China.
¹³ School of Biological Sciences, Queen's University of Belfast, Belfast, UK.
¹⁴ Functional Proteomics Laboratory, Centro Nacional de Biotecnología-CSIC, Madrid, Spain.
¹⁵ Computational Systems Biochemistry Research Group, Max-Planck Institute of Biochemistry, Martinsried, Germany.
¹⁶ AI for Science Institute, Beijing, China.
¹⁷ Center for Machine Learning Research, Peking University, Beijing, China.
¹⁸ Advanced Clinical Biosystems Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA.
¹⁹ Department of Liver Surgery and Transplantation, Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
²⁰ Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
²¹ Monash Proteomics and Metabolomics Platform, Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.
²² School of Pharmaceutical Sciences and Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
²³ The D. H. Chen School of Universal Health, Zhejiang University, Hangzhou, China.
²⁴ Pengcheng Laboratory, Shenzhen, China.
²⁵ School of Electronic Engineering and Computer Science, Peking University, Beijing, China.
²⁶ Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
²⁷ Department of Chemistry, University of Tokyo, Tokyo, Japan.
²⁸ Department of Bioengineering, University of California, Los Angeles, California, USA.
²⁹ Institute of Technological Sciences, Wuhan University, Wuhan, Hubei, China.
³⁰ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
³¹ School of Medicine, Southern University of Science and Technology, Shenzhen, China.
³² Department of Nutrition, Tianjin Institute of Environmental and Operational Medicine, Tianjin, China.
³³ School of Medicine, Westlake University, Hangzhou, China.
³⁴ Westlake Center for Intelligent Proteomics, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
³⁵ Research Center for Industries of the Future, School of Life Sciences, Westlake University, Hangzhou, China.
³⁶ International Academy of Phronesis Medicine (Guangdong), Guangdong, China.
³⁷ Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, the Netherlands.
³⁸ Netherlands Proteomics Center, Utrecht, the Netherlands.
³⁹ European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.
⁴⁰ Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
⁴¹ Department of Head & Neck Surgery, Division of Surgery & Surgical Oncology, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore.
⁴² OncoProteomics Laboratory, Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
⁴³ Advanced Glycoscience Research Cluster, School of Biological and Chemical Sciences, University of Galway, Galway, Ireland.
⁴⁴ Departments of Molecular Biosciences, Departments of Chemistry, Northwestern University, Evanston, IL, USA.
⁴⁵ David R. Cheriton School of Computer Science, University of Waterloo, Waterloo, Ontario, Canada.
⁴⁶ Central China Institute of Artificial Intelligence, Henan, China.
⁴⁷ Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore.
⁴⁸ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
⁴⁹ Department of Structural Biology, Leibniz-Forschungsinstitut für MolekularePharmakologie (FMP), Berlin, Germany.
⁵⁰ State Key Laboratory of Membrane Biology, Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
⁵¹ Cancer Biology Institute, Yale University School of Medicine, West Haven, CT, USA.
⁵² State Key Laboratory of Molecular Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⁵³ UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
⁵⁴ Department of Critical Care Medicine and Hematology, The Third Xiangya Hospital, Central South University; Department of Hematology and Critical Care Medicine, The Third Xiangya Hospital, Central South University, Changsha, China.
⁵⁵ Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
⁵⁶ School of Life Sciences, Tsinghua University, Tsinghua-Peking Center for Life Sciences, Beijing, China.
⁵⁷ Institute for Systems Biology, Seattle, WA, USA.
⁵⁸ Clinical Biomarker Discovery and Validation, Monash University, Clayton, Victoria, Australia.
⁵⁹ Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁶⁰ Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai, China.
⁶¹ Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁶² Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
⁶³ Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
⁶⁴ Yonsei Frontier Lab, Yonsei University, Seoul, Republic of Korea.
⁶⁵ Glycoproteomics Laboratory, Department of Parasitology, University of São Paulo, Sao Paulo, Brazil.
⁶⁶ Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
⁶⁷ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.
⁶⁸ University of the Chinese Academy of Sciences, Beijing, China.
⁶⁹ Institut de Recherche en Santé Environnement et Travail, Univ. Rennes, Inserm, EHESP, Irset, Rennes, France.
⁷⁰ Pilot Laboratory, MOE Frontier Science Centre for Precision Oncology, Centre for Precision Medicine Research and Training, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau, China.
⁷¹ Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
⁷² State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
⁷³ ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, New South Wales, Australia.
⁷⁴ Department of Health Sciences, University Magna Græcia of Catanzaro, Catanzaro, Italy.
⁷⁵ Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
⁷⁶ Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁷⁷ State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.
⁷⁸ Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
⁷⁹ Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
⁸⁰ Indian Institute of Technology Bombay, Mumbai, India.
⁸¹ Department of Health Sciences, Faculty of Applied Health Sciences, Brock University, St. Catharines, Ontario, Canada.
⁸² Center for Quantitative Biology, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
⁸³ Department of Chemistry, Southern University of Science and Technology, Shenzhen, China.
⁸⁴ State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.
⁸⁵ Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China.
⁸⁶ Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
⁸⁷ Technical University of Munich, Freising, Germany.
⁸⁸ Advanced Genomics Unit, Center for Research and Advanced Studies, Irapuato, Mexico.
⁸⁹ Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
⁹⁰ Department of Computer Science, National University of Singapore, Singapore, Singapore.
⁹¹ Department of Pathology, National University of Singapore, Singapore, Singapore.
⁹² Guangzhou National Laboratory, Guangzhou, China.
⁹³ School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, China.
⁹⁴ The Scripps Research Institute, La Jolla, CA, USA.
⁹⁵ China Science and Technology Exchange Center, Beijing, China.
⁹⁶ CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
⁹⁷ Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.
⁹⁸ Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
⁹⁹ Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
¹⁰⁰ State Key Laboratory of Medical Proteomics, National Chromatography R. & A. Center, CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
¹⁰¹ School of Mathematical Sciences, Peking University, Beijing, China.
¹⁰² Wuhan University, Wuhan, China.

PMID: 39663494
DOI: 10.1038/s41586-024-08280-5

Review

π-HuB: the proteomic navigator of the human body

Fuchu He et al. Nature. 2024 Dec.

. 2024 Dec;636(8042):322-331.

doi: 10.1038/s41586-024-08280-5. Epub 2024 Dec 11.

Authors

Collaborators

π-HuB Consortium:
Daniel W Chan, Chris Soon Heng Tan, Weinan E, Jennifer E Van Eyk, Mingxia Gao, Qiang Gao, Yushun Gao, Xuejiang Guo, Jie He, Jun He, Qing-Yu He, Jinlin Hou, Canhua Huang, Chenxi Jia, Bernhard Kuster, Chaoying Li, Dong Li, Yan Li, Yanchang Li, Siqi Liu, Xiaonan Liu, Ya Liu, Zhongyang Liu, Haojie Lu, Yongzhan Nie, Mariko Okada, Guojun Qian, Hongqiang Qin, Yu Rao, Zihe Rao, Xianwen Ren, Yan Ren, Feng Shen, Lin Shen, Shicheng Su, Minjia Tan, Ben Zhong Tang, Sheng-Ce Tao, Jian Wang, Tong Wang, Liming Wei, Catherine C L Wong, Xiaoliang Sunney Xie, Li Xu, Ping Xu, Tao Xu, Huanming Yang, Jianjun Yang, Mingliang Ye, Wantao Ying, Xiaobo Yu, Yaxiang Yuan, Qingcun Zeng, Qimin Zhan, Xiaofei Zhang, Xu Zhang, Ying Zhang, Nan-Shan Zhong, Feng Zhou, Yi Zhu, Zemin Zhang

Affiliations

¹ State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China. hefc@bmi.ac.cn.
² International Academy of Phronesis Medicine (Guangdong), Guangdong, China. hefc@bmi.ac.cn.
³ Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland. aebersold@imsb.biol.ethz.ch.
⁴ Macquarie Medical School, Macquarie University, Sydney, New South Wales, Australia.
⁵ Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University) and Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China.
⁶ Institute of Health Service and Transfusion Medicine, Beijing, China.
⁷ Department of Pathology and The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.
⁸ State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
⁹ Key Laboratory of Systems Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.
¹⁰ Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, China.
¹¹ Institute of Chemistry, Academia Sinica, Taipei, China.
¹² National Biomedical Imaging Center, State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, College of Future Technology, Peking University, Beijing, China.
¹³ School of Biological Sciences, Queen's University of Belfast, Belfast, UK.
¹⁴ Functional Proteomics Laboratory, Centro Nacional de Biotecnología-CSIC, Madrid, Spain.
¹⁵ Computational Systems Biochemistry Research Group, Max-Planck Institute of Biochemistry, Martinsried, Germany.
¹⁶ AI for Science Institute, Beijing, China.
¹⁷ Center for Machine Learning Research, Peking University, Beijing, China.
¹⁸ Advanced Clinical Biosystems Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA.
¹⁹ Department of Liver Surgery and Transplantation, Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
²⁰ Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
²¹ Monash Proteomics and Metabolomics Platform, Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.
²² School of Pharmaceutical Sciences and Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
²³ The D. H. Chen School of Universal Health, Zhejiang University, Hangzhou, China.
²⁴ Pengcheng Laboratory, Shenzhen, China.
²⁵ School of Electronic Engineering and Computer Science, Peking University, Beijing, China.
²⁶ Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
²⁷ Department of Chemistry, University of Tokyo, Tokyo, Japan.
²⁸ Department of Bioengineering, University of California, Los Angeles, California, USA.
²⁹ Institute of Technological Sciences, Wuhan University, Wuhan, Hubei, China.
³⁰ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
³¹ School of Medicine, Southern University of Science and Technology, Shenzhen, China.
³² Department of Nutrition, Tianjin Institute of Environmental and Operational Medicine, Tianjin, China.
³³ School of Medicine, Westlake University, Hangzhou, China.
³⁴ Westlake Center for Intelligent Proteomics, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
³⁵ Research Center for Industries of the Future, School of Life Sciences, Westlake University, Hangzhou, China.
³⁶ International Academy of Phronesis Medicine (Guangdong), Guangdong, China.
³⁷ Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, the Netherlands.
³⁸ Netherlands Proteomics Center, Utrecht, the Netherlands.
³⁹ European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.
⁴⁰ Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
⁴¹ Department of Head & Neck Surgery, Division of Surgery & Surgical Oncology, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore.
⁴² OncoProteomics Laboratory, Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
⁴³ Advanced Glycoscience Research Cluster, School of Biological and Chemical Sciences, University of Galway, Galway, Ireland.
⁴⁴ Departments of Molecular Biosciences, Departments of Chemistry, Northwestern University, Evanston, IL, USA.
⁴⁵ David R. Cheriton School of Computer Science, University of Waterloo, Waterloo, Ontario, Canada.
⁴⁶ Central China Institute of Artificial Intelligence, Henan, China.
⁴⁷ Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore.
⁴⁸ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
⁴⁹ Department of Structural Biology, Leibniz-Forschungsinstitut für MolekularePharmakologie (FMP), Berlin, Germany.
⁵⁰ State Key Laboratory of Membrane Biology, Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
⁵¹ Cancer Biology Institute, Yale University School of Medicine, West Haven, CT, USA.
⁵² State Key Laboratory of Molecular Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⁵³ UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
⁵⁴ Department of Critical Care Medicine and Hematology, The Third Xiangya Hospital, Central South University; Department of Hematology and Critical Care Medicine, The Third Xiangya Hospital, Central South University, Changsha, China.
⁵⁵ Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
⁵⁶ School of Life Sciences, Tsinghua University, Tsinghua-Peking Center for Life Sciences, Beijing, China.
⁵⁷ Institute for Systems Biology, Seattle, WA, USA.
⁵⁸ Clinical Biomarker Discovery and Validation, Monash University, Clayton, Victoria, Australia.
⁵⁹ Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁶⁰ Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai, China.
⁶¹ Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁶² Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
⁶³ Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
⁶⁴ Yonsei Frontier Lab, Yonsei University, Seoul, Republic of Korea.
⁶⁵ Glycoproteomics Laboratory, Department of Parasitology, University of São Paulo, Sao Paulo, Brazil.
⁶⁶ Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
⁶⁷ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.
⁶⁸ University of the Chinese Academy of Sciences, Beijing, China.
⁶⁹ Institut de Recherche en Santé Environnement et Travail, Univ. Rennes, Inserm, EHESP, Irset, Rennes, France.
⁷⁰ Pilot Laboratory, MOE Frontier Science Centre for Precision Oncology, Centre for Precision Medicine Research and Training, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau, China.
⁷¹ Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
⁷² State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
⁷³ ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, New South Wales, Australia.
⁷⁴ Department of Health Sciences, University Magna Græcia of Catanzaro, Catanzaro, Italy.
⁷⁵ Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
⁷⁶ Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁷⁷ State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.
⁷⁸ Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
⁷⁹ Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
⁸⁰ Indian Institute of Technology Bombay, Mumbai, India.
⁸¹ Department of Health Sciences, Faculty of Applied Health Sciences, Brock University, St. Catharines, Ontario, Canada.
⁸² Center for Quantitative Biology, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
⁸³ Department of Chemistry, Southern University of Science and Technology, Shenzhen, China.
⁸⁴ State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.
⁸⁵ Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China.
⁸⁶ Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
⁸⁷ Technical University of Munich, Freising, Germany.
⁸⁸ Advanced Genomics Unit, Center for Research and Advanced Studies, Irapuato, Mexico.
⁸⁹ Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
⁹⁰ Department of Computer Science, National University of Singapore, Singapore, Singapore.
⁹¹ Department of Pathology, National University of Singapore, Singapore, Singapore.
⁹² Guangzhou National Laboratory, Guangzhou, China.
⁹³ School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, China.
⁹⁴ The Scripps Research Institute, La Jolla, CA, USA.
⁹⁵ China Science and Technology Exchange Center, Beijing, China.
⁹⁶ CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
⁹⁷ Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.
⁹⁸ Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
⁹⁹ Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
¹⁰⁰ State Key Laboratory of Medical Proteomics, National Chromatography R. & A. Center, CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
¹⁰¹ School of Mathematical Sciences, Peking University, Beijing, China.
¹⁰² Wuhan University, Wuhan, China.

PMID: 39663494
DOI: 10.1038/s41586-024-08280-5

Erratum in

Author Correction: π-HuB: the proteomic navigator of the human body.
He F, Aebersold R, Baker MS, Bian X, Bo X, Chan DW, Chang C, Chen L, Chen X, Chen YJ, Cheng H, Collins BC, Corrales F, Cox J, E W, Van Eyk JE, Fan J, Faridi P, Figeys D, Gao GF, Gao W, Gao ZH, Goda K, Goh WWB, Gu D, Guo C, Guo T, He Y, Heck AJR, Hermjakob H, Hunter T, Iyer NG, Jiang Y, Jimenez CR, Joshi L, Kelleher NL, Li M, Li Y, Lin Q, Liu CH, Liu F, Liu GH, Liu Y, Liu Z, Low TY, Lu B, Mann M, Meng A, Moritz RL, Nice E, Ning G, Omenn GS, Overall CM, Palmisano G, Peng Y, Pineau C, Poon TCW, Purcell AW, Qiao J, Reddel RR, Robinson PJ, Roncada P, Sander C, Sha J, Song E, Srivastava S, Sun A, Sze SK, Tang C, Tang L, Tian R, Vizcaíno JA, Wang C, Wang C, Wang X, Wang X, Wang Y, Weiss T, Wilhelm M, Winkler R, Wollscheid B, Wong L, Xie L, Xie W, Xu T, Xu T, Yan L, Yang J, Yang X, Yates J, Yun T, Zhai Q, Zhang B, Zhang H, Zhang L, Zhang L, Zhang P, Zhang Y, Zheng YZ, Zhong Q, Zhu Y; π-HuB Consortium. He F, et al. Nature. 2025 Jan;637(8046):E22. doi: 10.1038/s41586-024-08555-x. Nature. 2025. PMID: 39715925 No abstract available.

Abstract

The human body contains trillions of cells, classified into specific cell types, with diverse morphologies and functions. In addition, cells of the same type can assume different states within an individual's body during their lifetime. Understanding the complexities of the proteome in the context of a human organism and its many potential states is a necessary requirement to understanding human biology, but these complexities can neither be predicted from the genome, nor have they been systematically measurable with available technologies. Recent advances in proteomic technology and computational sciences now provide opportunities to investigate the intricate biology of the human body at unprecedented resolution and scale. Here we introduce a big-science endeavour called π-HuB (proteomic navigator of the human body). The aim of the π-HuB project is to (1) generate and harness multimodality proteomic datasets to enhance our understanding of human biology; (2) facilitate disease risk assessment and diagnosis; (3) uncover new drug targets; (4) optimize appropriate therapeutic strategies; and (5) enable intelligent healthcare, thereby ushering in a new era of proteomics-driven phronesis medicine. This ambitious mission will be implemented by an international collaborative force of multidisciplinary research teams worldwide across academic, industrial and government sectors.

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Conflict of interest statement

Competing interests: R.A. holds shares of Biognosys AG, which operates in the field covered by the article. D.F. is co-founder of MedBiome Inc., a precision nutrition company. K.G. is a shareholder of CYBO, LucasLand, and FlyWorks. T.G. is the founder of Westlake Omics Inc. M.M. is an indirect investor in EvoSep. R.T. is a founder of BayOmics. The other authors declare no competing interests.

References

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π-HuB: the proteomic navigator of the human body

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π-HuB: the proteomic navigator of the human body

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