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. 1979 Sep-Oct;1(5):845-51.
doi: 10.1093/clinids/1.5.845.

Effects of subminimal inhibitory concentrations of antibiotics on adhesiveness of Escherichia coli in vitro

K Vosbeck, H Handschin, E B Menge, O Zak

Effects of subminimal inhibitory concentrations of antibiotics on adhesiveness of Escherichia coli in vitro

K Vosbeck et al. Rev Infect Dis. 1979 Sep-Oct.

Abstract

The adhesion of radiolabeled Escherichia coli (strain SS142) to monolayers of Intestine 407, a human epithelioid tissue culture cell line, was investigated. In this assay the adhesion of bacteria grown in the presence of subminimal inhibitory concentrations of tetracycline, clindamycin,, or trimethoprim-sulfametrole was reduced in a manner that was dose dependent. In contrast, at such concentrations nalidixic acid enhanced the adhesion of this bacterial strain, and other antibiotics-e.g., penicillin G, ampicillin, mecillinam, cephacetrile, cephalexin, cefotaxime, chloramphenicol, and streptomycin-did not affect its adhesiveness.

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