Multicenter Study

. 2025 May 15;27(4):1102-1115.

doi: 10.1093/neuonc/noae260.

Machine learning-based prognostic subgrouping of glioblastoma: A multicenter study

Hamed Akbari¹, Spyridon Bakas^{2

3

4

5}, Chiharu Sako^{6

7

8}, Anahita Fathi Kazerooni^{9

10}, Javier Villanueva-Meyer¹¹, Jose A Garcia^{6

7

8}, Elizabeth Mamourian^{6

7

8}, Fang Liu^{12

13}, Quy Cao^{12

13}, Russell T Shinohara^{6

8

12

13}, Ujjwal Baid^{2

3}, Alexander Getka^{6

7

8}, Sarthak Pati², Ashish Singh^{6

7

8}, Evan Calabrese¹⁴, Susan Chang¹⁵, Jeffrey Rudie¹⁶, Aristeidis Sotiras¹⁷, Pamela LaMontagne¹⁷, Daniel S Marcus¹⁷, Mikhail Milchenko¹⁷, Arash Nazeri¹⁷, Carmen Balana¹⁸, Jaume Capellades¹⁹, Josep Puig²⁰, Chaitra Badve²¹, Jill S Barnholtz-Sloan^{22

23

24}, Andrew E Sloan^{25

26}, Vachan Vadmal²⁷, Kristin Waite^{24

27}, Murat Ak²⁸, Rivka R Colen^{28

29}, Yae Won Park³⁰, Sung Soo Ahn³⁰, Jong Hee Chang^{31

32}, Yoon Seong Choi^{33

34}, Seung-Koo Lee³⁰, Gregory S Alexander³⁵, Ayesha S Ali³⁵, Adam P Dicker³⁵, Adam E Flanders³⁶, Spencer Liem³⁵, Joseph Lombardo^{37

35}, Wenyin Shi³⁵, Gaurav Shukla^{6

8

35

38}, Brent Griffith³⁹, Laila M Poisson^{40

41}, Lisa R Rogers⁴¹, Aikaterini Kotrotsou⁴², Thomas C Booth^{43

44}, Rajan Jain^{45

46}, Matthew Lee⁴⁵, Abhishek Mahajan^{47

48}, Arnab Chakravarti⁴⁹, Joshua D Palmer⁴⁹, Dominic DiCostanzo⁴⁹, Hassan Fathallah-Shaykh⁵⁰, Santiago Cepeda⁵¹, Orazio Santo Santonocito⁵², Anna Luisa Di Stefano⁵², Benedikt Wiestler⁵³, Elias R Melhem⁵⁴, Graeme F Woodworth^{54

55}, Pallavi Tiwari^{56

57}, Pablo Valdes⁵⁸, Yuji Matsumoto⁵⁹, Yoshihiro Otani⁵⁹, Ryoji Imoto⁵⁹, Mariam Aboian⁷, Shinichiro Koizumi⁶⁰, Kazuhiko Kurozumi⁶⁰, Toru Kawakatsu⁶⁰, Kimberley Alexander^{61

62

63}, Laveniya Satgunaseelan^{61

62

63}, Aaron M Rulseh⁶⁴, Stephen J Bagley^{65

66}, Michel Bilello^{6

7

8}, Zev A Binder^{9

66}, Steven Brem^{9

66}, Arati S Desai⁶⁶, Robert A Lustig⁶⁷, Eileen Maloney⁹, Timothy Prior⁹, Nduka Amankulor^{9

66}, MacLean P Nasrallah^{6

8

66

68}, Donald M O'Rourke^{9

66}, Suyash Mohan^{6

7

8}, Christos Davatzikos^{6

7

8}; ReSPOND consortium

Collaborators, Affiliations

Collaborators

ReSPOND consortium:
Christos Davatzikos

Affiliations

¹ Department of Bioengineering, School of Engineering, Santa Clara University, Santa Clara, California, USA.
² Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
³ Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
⁴ Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
⁵ Department of Computer Science, Luddy School of Informatics, Computing, and Engineering, Indiana University, Indianapolis, Indiana, USA.
⁶ Center for Data Science and AI for Integrated Diagnostics (AI2D), and Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁷ Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁸ Penn Statistics in Imaging and Visualization Center, and Center for Clinical Epidemiology ce and AI for Integrated Diagnostics (AI2D), and Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁹ Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
¹⁰ Center for Data-Driven Discovery in Biomedicine (D3b), Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
¹¹ Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
¹² Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
¹³ Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
¹⁴ Department of Radiology, Duke University, Durham, North Carolina, USA.
¹⁵ Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA.
¹⁶ Department of Radiology, University of California San Diego, San Diego, California, USA.
¹⁷ Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
¹⁸ B-ARGO Group, Institut Investigació Germans Trias i Pujol (IGTP), Badalona (Barcelona), Catalonia, Spain.
¹⁹ Research Unit (IDIR), Image Diagnosis Institute, Badalona, Spain.
²⁰ Department of Radiology (CDI), Hospital Clínic and IDIBAPS, Barcelona, Spain.
²¹ Department of Radiology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, USA.
²² Trans-Divisional Research Program (TDRP), Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, Bethesda, Maryland, USA.
²³ Central Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.
²⁴ Center for Biomedical Informatics and Information Technology (CBIIT), National Cancer Institute, Bethesda, Maryland, USA.
²⁵ Brain and Tumor Neurosurgery, Neurosurgical Oncology, Piedmont Health, Atlanta, Georgia, USA.
²⁶ Seidman Cancer Center and Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA.
²⁷ Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
²⁸ Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
²⁹ Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
³⁰ Department of Radiology, Yonsei University College of Medicine, Seoul, Republic of Korea.
³¹ Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Republic of Korea.
³² Brain Tumor Center, Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea.
³³ Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
³⁴ Clinical Imaging Research Centre, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
³⁵ Department of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
³⁶ Department of Radiology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
³⁷ Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
³⁸ Department of Radiation Oncology, Christiana Care Health System, Philadelphia, Pennsylvania, USA.
³⁹ Department of Radiology, Henry Ford Health System, Detroit, Michigan, USA.
⁴⁰ Department of Public Health Sciences, Center for Bioinformatics, Henry Ford Health System, Detroit, Michigan, USA.
⁴¹ Department of Neurosurgery, Hermelin Brain Tumor Center, Henry Ford Cancer Institute, Henry Ford Health, Detroit, Michigan, USA.
⁴² MD Anderson Cancer Center, University of Texas, Houston, Texas, USA.
⁴³ School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
⁴⁴ Department of Neuroradiology, Ruskin Wing, King's College Hospital NHS Foundation Trust, London, UK.
⁴⁵ Department of Radiology, New York University Langone Health, New York, New York, USA.
⁴⁶ Department of Neurosurgery, New York University Langone Health, New York, New York, USA.
⁴⁷ Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
⁴⁸ The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, UK.
⁴⁹ Department of Radiation Oncology, The James Cancer Hospital at the Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
⁵⁰ Department of Neurology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
⁵¹ Department of Neurosurgery, University Hospital Río Hortega, Valladolid, Spain.
⁵² Division of Neurosurgery, Spedali Riuniti di Livorno-Azienda USL Toscana Nord-Ovest, Livorno, Italy.
⁵³ Department of Neuroradiology, Technical University of Munich, Munchen, Germany.
⁵⁴ Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
⁵⁵ Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
⁵⁶ Department of Radiology, University of Wisconsin, Madison, Wisconsin, USA.
⁵⁷ Department of Biomedical Engineering, University of Wisconsin, Madison, Wisconsin, USA.
⁵⁸ Department of Neurosurgery, University of Texas Medical Branch, Galveston, Texas, USA.
⁵⁹ Department of Neurological Surgery, Okayama University, Okayama, Japan.
⁶⁰ Department of Neurosurgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
⁶¹ Department of Neurosurgery, Chris O'Brien Lifehouse, Camperdown, Australia.
⁶² Faculty of Medicine and Health, University of Sydney, Camperdown, Australia.
⁶³ Department of Neuropathology, Royal Prince Alfred Hospital, Camperdown, Australia.
⁶⁴ Department of Radiology, Na Homolce Hospital, Prague, Czechia.
⁶⁵ Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁶⁶ GBM Translational Center of Excellence, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁶⁷ Department of Radiation-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁶⁸ Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

PMID: 39665363
PMCID: PMC12083074
DOI: 10.1093/neuonc/noae260

Multicenter Study

Machine learning-based prognostic subgrouping of glioblastoma: A multicenter study

Hamed Akbari et al. Neuro Oncol. 2025.

. 2025 May 15;27(4):1102-1115.

doi: 10.1093/neuonc/noae260.

Authors

Collaborators

ReSPOND consortium:
Christos Davatzikos

Affiliations

¹ Department of Bioengineering, School of Engineering, Santa Clara University, Santa Clara, California, USA.
² Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
³ Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
⁴ Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
⁵ Department of Computer Science, Luddy School of Informatics, Computing, and Engineering, Indiana University, Indianapolis, Indiana, USA.
⁶ Center for Data Science and AI for Integrated Diagnostics (AI2D), and Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁷ Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁸ Penn Statistics in Imaging and Visualization Center, and Center for Clinical Epidemiology ce and AI for Integrated Diagnostics (AI2D), and Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁹ Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
¹⁰ Center for Data-Driven Discovery in Biomedicine (D3b), Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
¹¹ Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
¹² Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
¹³ Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
¹⁴ Department of Radiology, Duke University, Durham, North Carolina, USA.
¹⁵ Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA.
¹⁶ Department of Radiology, University of California San Diego, San Diego, California, USA.
¹⁷ Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
¹⁸ B-ARGO Group, Institut Investigació Germans Trias i Pujol (IGTP), Badalona (Barcelona), Catalonia, Spain.
¹⁹ Research Unit (IDIR), Image Diagnosis Institute, Badalona, Spain.
²⁰ Department of Radiology (CDI), Hospital Clínic and IDIBAPS, Barcelona, Spain.
²¹ Department of Radiology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, USA.
²² Trans-Divisional Research Program (TDRP), Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, Bethesda, Maryland, USA.
²³ Central Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.
²⁴ Center for Biomedical Informatics and Information Technology (CBIIT), National Cancer Institute, Bethesda, Maryland, USA.
²⁵ Brain and Tumor Neurosurgery, Neurosurgical Oncology, Piedmont Health, Atlanta, Georgia, USA.
²⁶ Seidman Cancer Center and Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA.
²⁷ Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
²⁸ Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
²⁹ Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
³⁰ Department of Radiology, Yonsei University College of Medicine, Seoul, Republic of Korea.
³¹ Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Republic of Korea.
³² Brain Tumor Center, Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea.
³³ Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
³⁴ Clinical Imaging Research Centre, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
³⁵ Department of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
³⁶ Department of Radiology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
³⁷ Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
³⁸ Department of Radiation Oncology, Christiana Care Health System, Philadelphia, Pennsylvania, USA.
³⁹ Department of Radiology, Henry Ford Health System, Detroit, Michigan, USA.
⁴⁰ Department of Public Health Sciences, Center for Bioinformatics, Henry Ford Health System, Detroit, Michigan, USA.
⁴¹ Department of Neurosurgery, Hermelin Brain Tumor Center, Henry Ford Cancer Institute, Henry Ford Health, Detroit, Michigan, USA.
⁴² MD Anderson Cancer Center, University of Texas, Houston, Texas, USA.
⁴³ School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
⁴⁴ Department of Neuroradiology, Ruskin Wing, King's College Hospital NHS Foundation Trust, London, UK.
⁴⁵ Department of Radiology, New York University Langone Health, New York, New York, USA.
⁴⁶ Department of Neurosurgery, New York University Langone Health, New York, New York, USA.
⁴⁷ Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
⁴⁸ The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, UK.
⁴⁹ Department of Radiation Oncology, The James Cancer Hospital at the Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
⁵⁰ Department of Neurology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
⁵¹ Department of Neurosurgery, University Hospital Río Hortega, Valladolid, Spain.
⁵² Division of Neurosurgery, Spedali Riuniti di Livorno-Azienda USL Toscana Nord-Ovest, Livorno, Italy.
⁵³ Department of Neuroradiology, Technical University of Munich, Munchen, Germany.
⁵⁴ Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
⁵⁵ Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
⁵⁶ Department of Radiology, University of Wisconsin, Madison, Wisconsin, USA.
⁵⁷ Department of Biomedical Engineering, University of Wisconsin, Madison, Wisconsin, USA.
⁵⁸ Department of Neurosurgery, University of Texas Medical Branch, Galveston, Texas, USA.
⁵⁹ Department of Neurological Surgery, Okayama University, Okayama, Japan.
⁶⁰ Department of Neurosurgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
⁶¹ Department of Neurosurgery, Chris O'Brien Lifehouse, Camperdown, Australia.
⁶² Faculty of Medicine and Health, University of Sydney, Camperdown, Australia.
⁶³ Department of Neuropathology, Royal Prince Alfred Hospital, Camperdown, Australia.
⁶⁴ Department of Radiology, Na Homolce Hospital, Prague, Czechia.
⁶⁵ Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁶⁶ GBM Translational Center of Excellence, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁶⁷ Department of Radiation-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁶⁸ Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

PMID: 39665363
PMCID: PMC12083074
DOI: 10.1093/neuonc/noae260

Abstract

Background: Glioblastoma (GBM) is the most aggressive adult primary brain cancer, characterized by significant heterogeneity, posing challenges for patient management, treatment planning, and clinical trial stratification.

Methods: We developed a highly reproducible, personalized prognostication, and clinical subgrouping system using machine learning (ML) on routine clinical data, magnetic resonance imaging (MRI), and molecular measures from 2838 demographically diverse patients across 22 institutions and 3 continents. Patients were stratified into favorable, intermediate, and poor prognostic subgroups (I, II, and III) using Kaplan-Meier analysis (Cox proportional model and hazard ratios [HR]).

Results: The ML model stratified patients into distinct prognostic subgroups with HRs between subgroups I-II and I-III of 1.62 (95% CI: 1.43-1.84, P < .001) and 3.48 (95% CI: 2.94-4.11, P < .001), respectively. Analysis of imaging features revealed several tumor properties contributing unique prognostic value, supporting the feasibility of a generalizable prognostic classification system in a diverse cohort.

Conclusions: Our ML model demonstrates extensive reproducibility and online accessibility, utilizing routine imaging data rather than complex imaging protocols. This platform offers a unique approach to personalized patient management and clinical trial stratification in GBM.

Keywords: glioblastoma; machine learning; mpMRI; prognostic subgrouping; survival.

© The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

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Figures

**Figure 1.**
Schematic illustration of machine learning (ML)-based subgrouping analysis pipeline.

**Figure 2.**
Overall survival map of all deceased ReSPOND patients. Brain regions associated with longer overall survival are shown on one end of the spectrum, while regions linked to shorter overall survival are shown on the opposite end. The color bar indicates the distribution of survival durations across the patient population. Abbreviation: ReSPOND = Radiomics Signatures for PrecisiON Diagnostics.

**Figure 3.**
Kaplan–Meier survival curves. Actual survival on the x-axis is compared among each of the 3 groups based on subgroups and integrated risk assessments. The top left panel shows Kaplan–Meier survival curves for 3 subgroups; the top right panel is boxplots of the subgroups versus the patients’ survival. On each box, the central line indicates the median and the bottom and top edges of the box indicate the 25th and 75th percentiles, respectively. The whiskers extend to the most extreme data points not considered outliers. The bottom panel shows Kaplan–Meier survival curves of integrated risk stratification with different combinations of predictors. Abbreviations: EOR = extent of resection; MGMT = O⁶-methylguanine-DNA methyltransferase; SPI = survival prediction index.

**Figure 4.**
Features versus actual survival of deceased patients in the full ReSPOND cohort. (A) The Concordance Index between patients’ survival and each feature. (B) The Concordance Index between SPI and OS per institution. (C) Boxplots of Z-scored features for short, medium, and long survival patients. On each box, the central mark indicates the median, and the bottom and top edges of the box indicate the 25th and 75th percentiles, respectively. Abbreviations: BV = brain volume; CAT = Catalan Institute of Oncology; CWRU = Case Western Reserve University; Dist2Vent = distance to ventricles; ED = volume of edema; ET = volume of enhancing tumor; HF = Henry Ford Health; KCL = King’s College London; MDA = MD Anderson Cancer Center; NC = volume of non-enhancing core; NYU = New York University; OS = overall survival; OSU = Ohio State University; Penn = University of Pennsylvania; ReSPOND = Radiomics Signatures for PrecisiON Diagnostics; RH = University Hospital Río Hortega; SM = overall survival map; SPI = survival prediction index; TC = volume of tumor core; TJU = Thomas Jefferson University; TMC = Tata Memorial Center; UAB = University of Alabama at Birmingham; UCSF = University of California, San Francisco; UPMC = University of Pittsburgh Medical Center; WashU = Washington University in St. Louis; WT = Volume of Whole Tumor.

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References

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Machine learning-based prognostic subgrouping of glioblastoma: A multicenter study

Collaborators

Affiliations

Machine learning-based prognostic subgrouping of glioblastoma: A multicenter study

Authors

Collaborators

Affiliations

Abstract

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical