doi: 10.1016/j.jacc.2024.10.106.
Epub 2024 Dec 11.
Real-World Efficacy and Safety of Inclisiran: A Single-Country, Multicenter, Observational Study (CHOLINET Registry)
Paola Gargiulo
1
, Federica Marzano
1
, Mario Crisci
2
, Rossella Marcucci
3
, Dario Bruzzese
4
, Alessandro Maloberti
5
, Filippo Maria Sarullo
6
, Gennaro Galasso
7
, Ciro Indolfi
8
, Giuseppe Musumeci
9
, Antonella Corleto
10
, Paolo Calabrò
11
, Stefano Carugo
12
, Gavino Casu
13
, Amedeo Picciolo
14
, Marco Matteo Ciccone
15
, Claudio Bilato
16
, Alberto Polimeni
17
, Francesco Giallauria
18
, Angelo Catalano
19
, Leonardo De Luca
20
, Giampaolo Niccoli
21
, Elio Venturini
22
, Marco Pepe
23
, Roberta Montisci
24
, Natale Daniele Brunetti
25
, Giuseppe Patti
26
, Italo Porto
27
, Alberto Margonato
28
, Marina Floresta
29
, Saverio Muscoli
30
, Matteo Cameli
31
, Giuseppe Andò
32
, Emilio Di Lorenzo
2
, Martina Berteotti
3
, Cristina Giannattasio
5
, Silvia Sarullo
33
, Ciro Formisano
7
, Assunta Di Costanzo
8
, Fabrizio Delnevo
9
, Ferdinando Varbella
10
, Arturo Cesaro
11
, Monica Franzese
34
, Costantino Mancusi
1
, Sara Fontanarosa
1
, Mariafrancesca Di Santo
1
, Ciro Cotticelli
1
, Fabrizio Perrone Filardi
1
, Stefania Paolillo
1
, Giovanni Esposito
1
, Alberto Corsini
35
, Pasquale Perrone Filardi
36
; CHOLINET Investigators
Affiliations
Affiliations
- 1 Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
- 2 Unit of Interventional Cardiology, AORN dei Colli, Monaldi Hospital, Naples, Italy.
- 3 Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
- 4 Department of Public Health, University of Naples Federico II, Naples, Italy.
- 5 Cardiology IV, "A. De Gasperis" Department, Ospedale Niguarda Ca' Granda, Milan, Italy; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
- 6 Cardiovascular Rehabilitation Unit, Buccheri La Ferla Fatebenefratelli Hospital, Palermo, Italy.
- 7 Department of Medicine, Surgery, and Dentistry, University of Salerno, Salerno, Italy.
- 8 Division of Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy.
- 9 Cardiology Division, AO Ordine Mauriziano, Turin, Italy.
- 10 Division of Cardiology, Interventional Unit, Infermi Rivoli Hospital Rivoli, San Luigi Gonzaga University Hospital, Orbassano, Italy.
- 11 Sant'Anna e San Sebastiano Hospital, Caserta, Italy; Division of Cardiology, University of Campania "Luigi Vanvitelli," Caserta, Italy.
- 12 Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy; Fondazione Ospedale Maggiore IRCCS Policlinico, Milan, Italy.
- 13 Department of Cardiology, Azienda Ospedaliera Universitaria of Sassari, Sassari, Italy.
- 14 Division of Cardiology, "V. Fazzi" Hospital, Lecce, Italy.
- 15 Section of Cardiovascular Diseases, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.
- 16 Division of Cardiology, West Vicenza General Hospitals, Arzignano, Vicenza, Italy.
- 17 Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy; Division of Interventional Cardiology, Annunziata Hospital, Cosenza, Italy.
- 18 Department of Translational Medical Sciences, Internal Medicine (Precision Medicine Unit), University of Naples Federico II, Naples, Italy.
- 19 Cardiology Unit, Hospital Maria SS. Addolorata, Eboli, Italy.
- 20 SC Cardiologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
- 21 Cardiology Division, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
- 22 Department of Cardiac Rehabilitation, Cecina Civil Hospital, Cecina (LI), Italy.
- 23 Casa di cura San Michele, Maddaloni, Italy.
- 24 Clinical Cardiology, AOU Cagliari, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.
- 25 Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
- 26 Division of Cardiology, Maggiore della Carità Hospital, University of Eastern Piedmont, Novara, Italy.
- 27 Cardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, IRCCS Italian Cardiology Network, Genova, Italy.
- 28 Cardiology Unit, Heart Valve Center, San Raffaele Hospital, Milan, Italy.
- 29 UOC Cardiologia e UTIC Villa Sofia, AOR Villa Sofia-Cervello, Palermo, Italy.
- 30 Division of Cardiology, Fondazione Policlinico Tor Vergata, Rome, Italy.
- 31 Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.
- 32 Department of Clinical and Experimental Medicine, University of Messina, AOU Policlinico "G. Martino," Messina, Italy.
- 33 BIND Department, Policlinico Paolo Giaccone University Hospital, University of Palermo, Palermo, Italy.
- 34 IRCCS Synlab SDN, Naples, Italy.
- 35 Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
- 36 Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy. Electronic address: fpperron@unina.it.
- PMID: 39665700
- DOI: 10.1016/j.jacc.2024.10.106
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Real-World Efficacy and Safety of Inclisiran: A Single-Country, Multicenter, Observational Study (CHOLINET Registry)
Paola Gargiulo et al.
J Am Coll Cardiol.
.
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doi: 10.1016/j.jacc.2024.10.106.
Epub 2024 Dec 11.
Authors
Paola Gargiulo
1
, Federica Marzano
1
, Mario Crisci
2
, Rossella Marcucci
3
, Dario Bruzzese
4
, Alessandro Maloberti
5
, Filippo Maria Sarullo
6
, Gennaro Galasso
7
, Ciro Indolfi
8
, Giuseppe Musumeci
9
, Antonella Corleto
10
, Paolo Calabrò
11
, Stefano Carugo
12
, Gavino Casu
13
, Amedeo Picciolo
14
, Marco Matteo Ciccone
15
, Claudio Bilato
16
, Alberto Polimeni
17
, Francesco Giallauria
18
, Angelo Catalano
19
, Leonardo De Luca
20
, Giampaolo Niccoli
21
, Elio Venturini
22
, Marco Pepe
23
, Roberta Montisci
24
, Natale Daniele Brunetti
25
, Giuseppe Patti
26
, Italo Porto
27
, Alberto Margonato
28
, Marina Floresta
29
, Saverio Muscoli
30
, Matteo Cameli
31
, Giuseppe Andò
32
, Emilio Di Lorenzo
2
, Martina Berteotti
3
, Cristina Giannattasio
5
, Silvia Sarullo
33
, Ciro Formisano
7
, Assunta Di Costanzo
8
, Fabrizio Delnevo
9
, Ferdinando Varbella
10
, Arturo Cesaro
11
, Monica Franzese
34
, Costantino Mancusi
1
, Sara Fontanarosa
1
, Mariafrancesca Di Santo
1
, Ciro Cotticelli
1
, Fabrizio Perrone Filardi
1
, Stefania Paolillo
1
, Giovanni Esposito
1
, Alberto Corsini
35
, Pasquale Perrone Filardi
36
; CHOLINET Investigators
Affiliations
- 1 Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
- 2 Unit of Interventional Cardiology, AORN dei Colli, Monaldi Hospital, Naples, Italy.
- 3 Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
- 4 Department of Public Health, University of Naples Federico II, Naples, Italy.
- 5 Cardiology IV, "A. De Gasperis" Department, Ospedale Niguarda Ca' Granda, Milan, Italy; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
- 6 Cardiovascular Rehabilitation Unit, Buccheri La Ferla Fatebenefratelli Hospital, Palermo, Italy.
- 7 Department of Medicine, Surgery, and Dentistry, University of Salerno, Salerno, Italy.
- 8 Division of Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy.
- 9 Cardiology Division, AO Ordine Mauriziano, Turin, Italy.
- 10 Division of Cardiology, Interventional Unit, Infermi Rivoli Hospital Rivoli, San Luigi Gonzaga University Hospital, Orbassano, Italy.
- 11 Sant'Anna e San Sebastiano Hospital, Caserta, Italy; Division of Cardiology, University of Campania "Luigi Vanvitelli," Caserta, Italy.
- 12 Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy; Fondazione Ospedale Maggiore IRCCS Policlinico, Milan, Italy.
- 13 Department of Cardiology, Azienda Ospedaliera Universitaria of Sassari, Sassari, Italy.
- 14 Division of Cardiology, "V. Fazzi" Hospital, Lecce, Italy.
- 15 Section of Cardiovascular Diseases, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.
- 16 Division of Cardiology, West Vicenza General Hospitals, Arzignano, Vicenza, Italy.
- 17 Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy; Division of Interventional Cardiology, Annunziata Hospital, Cosenza, Italy.
- 18 Department of Translational Medical Sciences, Internal Medicine (Precision Medicine Unit), University of Naples Federico II, Naples, Italy.
- 19 Cardiology Unit, Hospital Maria SS. Addolorata, Eboli, Italy.
- 20 SC Cardiologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
- 21 Cardiology Division, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
- 22 Department of Cardiac Rehabilitation, Cecina Civil Hospital, Cecina (LI), Italy.
- 23 Casa di cura San Michele, Maddaloni, Italy.
- 24 Clinical Cardiology, AOU Cagliari, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.
- 25 Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
- 26 Division of Cardiology, Maggiore della Carità Hospital, University of Eastern Piedmont, Novara, Italy.
- 27 Cardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, IRCCS Italian Cardiology Network, Genova, Italy.
- 28 Cardiology Unit, Heart Valve Center, San Raffaele Hospital, Milan, Italy.
- 29 UOC Cardiologia e UTIC Villa Sofia, AOR Villa Sofia-Cervello, Palermo, Italy.
- 30 Division of Cardiology, Fondazione Policlinico Tor Vergata, Rome, Italy.
- 31 Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.
- 32 Department of Clinical and Experimental Medicine, University of Messina, AOU Policlinico "G. Martino," Messina, Italy.
- 33 BIND Department, Policlinico Paolo Giaccone University Hospital, University of Palermo, Palermo, Italy.
- 34 IRCCS Synlab SDN, Naples, Italy.
- 35 Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
- 36 Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy. Electronic address: fpperron@unina.it.
- PMID: 39665700
- DOI: 10.1016/j.jacc.2024.10.106
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No abstract available
Keywords: LDL cholesterol; efficacy; inclisiran; safety.
Conflict of interest statement
Funding Support and Author Disclosures Dr Corsini has received consulting fees and lecture fees from Algorithm, Amarin, Amgen, DOC, Fidia, Novartis, Merck Sharp & Dohme, Recordati Spa, Sanofi, Servier, and Viatris; and has received grant support from Daiichi-Sankyo. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
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