Making Sense of 'Porto-Sinusoidal Vascular Disorder': What Does It Mean for the Pathologist and the Patient?

Alastair D Burt¹, Annette S H Gouw², Francesco Callea³, Andrew D Clouston⁴, Hans-Peter Dienes⁵, Zachary D Goodman⁶, Sanjay Kakar⁷, David E Kleiner⁸, Carolin Lackner⁹, Young Nyun Park¹⁰, Eve A Roberts¹¹, Peter Schirmacher¹², Luigi Terracciano¹³, Dina Tiniakos^{1

14}, Michael Torbenson¹⁵, Ian R Wanless¹⁶, Achim Weber¹⁷, Yoh Zen¹⁸

Affiliations

¹ Newcastle NIHR Biomedical Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
² Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, The Netherlands.
³ Ospedale Pediatrico Bambino Gesu, Rome, Italy.
⁴ Centre for Liver Disease Research, School of Medicine (Southern), University of Queensland, Princess Alexandra Hospital, Woolloongabba, Australia.
⁵ Institute of Pathology, Medical University of Vienna, Wien, Austria.
⁶ Center for Liver Diseases, Inova Fairfax Hospital, Falls Church, Virginia, USA.
⁷ Department of Pathology, University of California, San Francisco, California, USA.
⁸ Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
⁹ Institute of Pathology, Medical University of Graz, Graz, Austria.
¹⁰ Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea.
¹¹ Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada.
¹² Institute of Pathology, University Hospital, Heidelberg, Germany.
¹³ Department of Biomedical Sciences, Humanitas University, Milan, Italy.
¹⁴ Department of Pathology, Aretaieion Hospital, Medical School, National & Kapodistrian University of Athens, Athens, Greece.
¹⁵ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
¹⁶ Department of Pathology, Queen Elizabeth II Health Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
¹⁷ Department of Pathology and Molecular Pathology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
¹⁸ Institute of Liver Studies, King's College Hospital, London, UK.

PMID: 39665793
DOI: 10.1111/liv.16196

Editorial

Making Sense of 'Porto-Sinusoidal Vascular Disorder': What Does It Mean for the Pathologist and the Patient?

Alastair D Burt et al. Liver Int. 2025 Jan.

. 2025 Jan;45(1):e16196.

doi: 10.1111/liv.16196.

Authors

Affiliations

¹ Newcastle NIHR Biomedical Research Centre, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
² Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, The Netherlands.
³ Ospedale Pediatrico Bambino Gesu, Rome, Italy.
⁴ Centre for Liver Disease Research, School of Medicine (Southern), University of Queensland, Princess Alexandra Hospital, Woolloongabba, Australia.
⁵ Institute of Pathology, Medical University of Vienna, Wien, Austria.
⁶ Center for Liver Diseases, Inova Fairfax Hospital, Falls Church, Virginia, USA.
⁷ Department of Pathology, University of California, San Francisco, California, USA.
⁸ Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
⁹ Institute of Pathology, Medical University of Graz, Graz, Austria.
¹⁰ Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea.
¹¹ Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada.
¹² Institute of Pathology, University Hospital, Heidelberg, Germany.
¹³ Department of Biomedical Sciences, Humanitas University, Milan, Italy.
¹⁴ Department of Pathology, Aretaieion Hospital, Medical School, National & Kapodistrian University of Athens, Athens, Greece.
¹⁵ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
¹⁶ Department of Pathology, Queen Elizabeth II Health Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
¹⁷ Department of Pathology and Molecular Pathology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
¹⁸ Institute of Liver Studies, King's College Hospital, London, UK.

PMID: 39665793
DOI: 10.1111/liv.16196

No abstract available

Keywords: pathology; portal hypertension; porto‐sinusoidal vascular disease; porto‐sinusoidal vascular disorder.

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References

1. T. Roskams, A. Baptista, L. Bianchi, et al., “Histopathology of Portal Hypertension: A Practical Guideline,” Histopathology 42, no. 1 (2003): 2–13.
1. M. Guido, V. A. F. Alves, C. Balabaud, et al., “Histology of Portal Vascular Changes Associated With Idiopathic Non‐cirrhotic Portal Hypertension: Nomenclature and Definition,” Histopathology 74, no. 2 (2019): 219–226.
1. A. De Gottardi, P. E. Rautou, J. Schouten, et al., “Porto‐Sinusoidal Vascular Disease: Proposal and Description of a Novel Entity,” Lancet Gastroenterology & Hepatology 4, no. 5 (2019): 399–411.
1. M. Kmeid, X. Liu, S. Ballentine, and H. Lee, “Idiopathic Non‐cirrhotic Portal Hypertension and Porto‐Sinusoidal Vascular Disease: Review of Current Data,” Gastroenterology Research 14, no. 2 (2021): 49–65.
1. M. Premkumar and A. C. Anand, “Porto‐sinusoidal vascular disease: classification and clinical relevance,” Journal of Clinical and Experimental Hepatology 14, no. 5 (2024): 101396.

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Making Sense of 'Porto-Sinusoidal Vascular Disorder': What Does It Mean for the Pathologist and the Patient?

Affiliations

Making Sense of 'Porto-Sinusoidal Vascular Disorder': What Does It Mean for the Pathologist and the Patient?

Authors

Affiliations

References

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LinkOut - more resources

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