Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Feb;39(2):520-523.
doi: 10.1038/s41375-024-02470-w. Epub 2024 Dec 12.

Acute myeloid leukemia associated RUNX1 variants induce aberrant expression of transcription factor TCF4

Mylène Gerritsen #  1 , Florentien E M In 't Hout #  1   2 , Ruth Knops  1 , Bas L R Mandos  1 , Melanie Decker  3 , Tim Ripperger  3 , Bert A van der Reijden  1 , Joost H A Martens  4 , Joop H Jansen  5
Affiliations

Acute myeloid leukemia associated RUNX1 variants induce aberrant expression of transcription factor TCF4

Mylène Gerritsen et al. Leukemia. 2025 Feb.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: We used the publicly available Beat AML data viewer ( www.vizome.org ), BeatAML2.0. All patients gave informed consent to participate in this study, which had the approval and guidance of the Institutional Review Boards (IRB) at Oregon Health & Science University (OHSU), University of Utah, University of Texas Medical Center (UT Southwestern), Stanford University, University of Miami, University of Colorado, University of Florida, National Institutes of Health (NIH), Fox Chase Cancer Center and University of Kansas (KUMC).

References

    1. Bullinger L, Dohner K, Dohner H. Genomics of Acute Myeloid Leukemia Diagnosis and Pathways. J Clin Oncol Off J Am Soc Clin Oncol. 2017;35:934–46. - DOI
    1. Arber DA, Orazi A, Hasserjian RP, Borowitz MJ, Calvo KR, Kvasnicka HM, et al. International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data. Blood. 2022;140:1200–28. - DOI - PubMed - PMC
    1. Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms. Leukemia. 2022;36:1703–19. - DOI - PubMed - PMC
    1. Dohner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H, et al. Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN. Blood. 2022;140:1345–77. - DOI - PubMed
    1. in ‘t Hout FE, van der Reijden BA, Monteferrario D, Jansen JH, Huls G. High expression of transcription factor 4 (TCF4) is an independent adverse prognostic factor in acute myeloid leukemia that could guide treatment decisions. Haematologica. 2014;99:e257–9. - DOI - PubMed - PMC

LinkOut - more resources