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Review
. 2025 Feb;174(2):203-212.
doi: 10.1111/imm.13882. Epub 2024 Dec 12.

The Role of Wnt5a in Inflammatory Diseases

Xin-Hua Yu  1 , Xin-Ning Guo  2 , Kui Li  3 , Jia-Wei Li  3 , Kaijin Wang  3 , Dan Wang  4 , Bi-Cui Liu  3
Affiliations
Review

The Role of Wnt5a in Inflammatory Diseases

Xin-Hua Yu et al. Immunology. 2025 Feb.

Abstract

Wnt5a plays an important role in cell development and maturation and is closely associated with various diseases, such as malignant tumours, metabolic disorders, fibrosis, growth and development. Recent studies have shown that Wnt5a expression and signal transduction are strongly involved in the inflammatory response. This study comprehensively reviewed the latest research progress on the association between Wnt5a and several inflammatory diseases, such as sepsis, asthma, chronic obstructive pulmonary disease, tuberculosis, rheumatoid arthritis, atherosclerosis and psoriasis vulgare. We elucidated the mechanism by which the Wnt5a protein is involved in the pathogenesis of these diseases, providing a basis for the prevention and treatment of inflammatory diseases.

Keywords: JAKs/STATs; Wnt5a; immune homeostasis; inflammation; inhibitory/activating receptors.

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References

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