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. 2024 Dec 1;13(6):937-949.
doi: 10.21037/hbsn-24-315. Epub 2024 Nov 5.

Liver venous deprivation (LVD) before extended hepatectomy: a French multicentric retrospective cohort

Mehdi Boubaddi  1 , Arthur Marichez  1 , Florian Pecquenard  2 , Charlotte Maulat  3 , Emmanuel Buc  4 , Laurent Sulpice  5 , Ahmet Ayav  6 , Stéphanie Truant  2 , Fabrice Muscari  3 , Laurence Chiche  1 , Christophe Laurent  1
Affiliations

Liver venous deprivation (LVD) before extended hepatectomy: a French multicentric retrospective cohort

Mehdi Boubaddi et al. Hepatobiliary Surg Nutr. .

Abstract

Background: Post-hepatectomy liver failure (PHLF) is the first cause of death after major hepatectomy, and future liver remnant (FLR) volume is the main factor predicting PHLF. Liver venous deprivation (LVD) via portal and hepatic vein embolization has been suggested to induce a better hypertrophy of the FLR than portal vein embolization. The aim of this retrospective multicentric study was to assess safety, feasibility and efficacity of LVD in a French national multicentric register.

Methods: Between 2016 and 2023, LVD was performed in 7 expert centers, for patients with liver malignancies requiring major hepatectomy with an FLR percentage of total liver volume (FLR%) ≤25% for a healthy liver or <30% for a diseased liver. FLR volumetry was assessed before and 4 weeks after the procedure.

Results: One hundred and ninety-two patients were included in the study. The technical success rate was 100% and severe complication rate post-LVD was 2.6% (5/192). The FLR% increased by 61.7% over an average of 27±9.7 days. Major hepatectomy was performed 40 days after LVD on 161 (83.8%) patients. Hepatectomy was not performed on 31 (16.2%) patients, mostly because of oncological progression. Severe postoperative complications (Clavien-Dindo grade ≥ IIIA) occurred in 21.1% (34/161) of patients. Postoperative mortality rate was 4.3% (7/161).

Conclusions: This study is the largest to confirm that LVD is a safe, reproducible, efficient technique that induces rapid major FLR growth. However, this new technique needs to be standardized and harmonized between centers to ensure uniform results.

Keywords: Liver venous deprivation (LVD); hepatectomy; liver hypertrophy; post-hepatectomy liver failure (PHLF).

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://hbsn.amegroups.com/article/view/10.21037/hbsn-24-315/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
A portogram taken after LVD. Two vascular plugs are visible in the right and median hepatic veins (white arrows). The volumetric data before and at 21 days post-LVD showed that the FLR increased by 60%. LVD, liver venous deprivation; FLR, future liver remnant.
Figure 2
Figure 2
Migration of a vascular plug into the vena cava after LVD. LVD, liver venous deprivation.
See this image and copyright information in PMC

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