Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2024 Dec 1;13(6):1022-1026.
doi: 10.21037/hbsn-24-521. Epub 2024 Nov 20.

Continuous normothermic machine perfusion of donor livers in the United States: the challenging road from the trial-world into the real-world

Otto B van Leeuwen  1 , Philipp Dutkowski  2 , Diethard Monbaliu  3 , Vincent E de Meijer  1
Affiliations
Editorial

Continuous normothermic machine perfusion of donor livers in the United States: the challenging road from the trial-world into the real-world

Otto B van Leeuwen et al. Hepatobiliary Surg Nutr. .
No abstract available

Keywords: Liver transplantation; machine perfusion; normothermic machine perfusion (NMP); randomized controlled trial (RCT).

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://hbsn.amegroups.com/article/view/10.21037/hbsn-24-521/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Overview of various machine perfusion techniques currently used in clinical practice. cNMP, continuous normothermic machine perfusion; e(D)HOPE, end-ischemic (dual) hypothermic oxygenated machine perfusion; eDHOPE-COR-NMP, sequential end-ischemic dual hypothermic oxygenated machine perfusion-controlled oxygenated rewarming-normothermic machine perfusion; NMP, normothermic machine perfusion; eNMP, end-ischemic normothermic machine perfusion; cHMPO2, continuous hypothermic machine perfusion with pre-oxygenation; IFLT, ischemia-free liver transplantation; SCS, static cold storage.
See this image and copyright information in PMC

Comment on

  • Normothermic Machine Perfusion of Donor Livers for Transplantation in the United States: A Randomized Controlled Trial.
    Chapman WC, Barbas AS, D'Alessandro AM, Vianna R, Kubal CA, Abt P, Sonnenday C, Barth R, Alvarez-Casas J, Yersiz H, Eckhoff D, Cannon R, Genyk Y, Sher L, Singer A, Feng S, Roll G, Cohen A, Doyle MB, Sudan DL, Al-Adra D, Khan A, Subramanian V, Abraham N, Olthoff K, Tekin A, Berg L, Coussios C, Morris C, Randle L, Friend P, Knechtle SJ. Chapman WC, et al. Ann Surg. 2023 Nov 1;278(5):e912-e921. doi: 10.1097/SLA.0000000000005934. Epub 2023 Jun 26. Ann Surg. 2023. PMID: 37389552 Clinical Trial.

References

    1. Guarrera JV, Henry SD, Samstein B, et al. Hypothermic machine preservation in human liver transplantation: the first clinical series. Am J Transplant 2010;10:372-81. 10.1111/j.1600-6143.2009.02932.x - DOI - PubMed
    1. Chapman WC, Barbas AS, D'Alessandro AM, et al. Normothermic Machine Perfusion of Donor Livers for Transplantation in the United States: A Randomized Controlled Trial. Ann Surg 2023;278:e912-21. 10.1097/SLA.0000000000005934 - DOI - PubMed
    1. Olthoff KM, Kulik L, Samstein B, et al. Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors. Liver Transpl 2010;16:943-9. 10.1002/lt.22091 - DOI - PubMed
    1. Nasralla D, Coussios CC, Mergental H, et al. A randomized trial of normothermic preservation in liver transplantation. Nature 2018;557:50-6. 10.1038/s41586-018-0047-9 - DOI - PubMed
    1. Dutkowski P, Guarrera JV, de Jonge J, et al. Evolving Trends in Machine Perfusion for Liver Transplantation. Gastroenterology 2019;156:1542-7. 10.1053/j.gastro.2018.12.037 - DOI - PubMed