Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2024 Jun 28:12:e17493.
doi: 10.7717/peerj.17493. eCollection 2024.

Impact of white blood cell count on the development of contrast-induced acute kidney injury in patients receiving percutaneous coronary intervention

Chengxiao Fu #  1   2 , Chenxi Ouyang #  3 , Guoping Yang  1   4 , Jingle Li  5 , Guiyang Chen  1   5 , Yu Cao  5 , Liying Gong  1   6
Affiliations
Observational Study

Impact of white blood cell count on the development of contrast-induced acute kidney injury in patients receiving percutaneous coronary intervention

Chengxiao Fu et al. PeerJ. .

Abstract

This study aimed to investigate the efficacy of a pre-procedural white blood cell (WBC) count in the prediction of contrast-induced acute kidney injury (CI-AKI) risk in coronary artery disease patients receiving a percutaneous coronary intervention (PCI). This observational study comprises a sample of 1,013 coronary artery disease patients (including ACS and stable angina) receiving PCI, gathered from September 2015 to July 2017. CI-AKI incidence in the study population was 4.8% (49/1013). Patients in the CI-AKI group had significantly higher WBC counts than those in the non-CI-AKI group (10.41 ± 5.37 vs. 8.09 ± 3.10, p = 0.004). Logistic analysis showed that WBC count (odds ratio [OR]: 1.12, 95% CI [1.03-1.21], P = 0.006) was a significant and independent predictor of CI-AKI risk in patients receiving PCI, Receiver-operating characteristic (ROC) curve analysis found that pre-procedural WBC count ≥11.03*109/L was the optimal cut-off value in the prediction of CI-AKI risk with a sensitivity of 41.0% and a specificity of 86.5%. Patients with CI-AKI had a significantly worse 1-year survival rate than patients without CI-AKI (91.8% vs. 97.6%, P = 0.012). In summary, increased pre-procedural WBC count is associated with an increased risk of developing CI-AKI in patients receiving PCI.

Keywords: Contrast-induced acute kidney injury; Coronary heart disease; Percutaneous coronary intervention; White blood cell.

PubMed Disclaimer

Conflict of interest statement

The authors declare there are no competing interests.

Figures

Figure 1
Figure 1. Flowchart depicting the inclusion and exclusion of the patients in the present study.
PCI indicates percutaneous coronary intervention; CI-AKI indicates contrast-induced acute kidney injury.
Figure 2
Figure 2. ROC curve analysis of the pro-procedure WBC count in predicting CI-AKI incidence in PCI patients.
Figure 3
Figure 3. Kaplan–Meier cumulative survival between patients with CI-AKI and non-CI-AKI.
See this image and copyright information in PMC

References

    1. Akcay A, Nguyen Q, Edelstein CL. Mediators of inflammation in acute kidney injury. Mediators of Inflammation. 2009;2009:137072. doi: 10.1155/2009/137072. - DOI - PMC - PubMed
    1. Akin F, Celik O, Altun I, Ayca B, Ozturk D, Satilmis S, Ayaz A, Tasbulak O. Relation of red cell distribution width to contrast-induced acute kidney injury in patients undergoing a primary percutaneous coronary intervention. Coronary Artery Disease. 2015;26:289–295. doi: 10.1097/MCA.0000000000000223. - DOI - PubMed
    1. Antoniades C, Bakogiannis C, Leeson P, Guzik TJ, Zhang MH, Tousoulis D, Antonopoulos AS, Demosthenous M, Marinou K, Hale A, Paschalis A, Psarros C, Triantafyllou C, Bendall J, Casadei B, Stefanadis C, Channon KM. Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling. Circulation. 2011;124:335–345. doi: 10.1161/CIRCULATIONAHA.110.985150. - DOI - PMC - PubMed
    1. Antoniades C, Bakogiannis C, Tousoulis D, Reilly S, Zhang MH, Paschalis A, Antonopoulos AS, Demosthenous M, Miliou A, Psarros C, Marinou K, Sfyras N, Economopoulos G, Casadei B, Channon KM, Stefanadis C. Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac1 and NADPH-oxidase activity. Circulation. 2010;122:S66–S73. doi: 10.1161/CIRCULATIONAHA.109.927376. - DOI - PubMed
    1. Ascer E, Bertolami MC, Venturinelli ML, Buccheri V, Souza J, Nicolau JC, Ramires JA, Serrano Jr CV. Atorvastatin reduces proinflammatory markers in hypercholesterolemic patients. Atherosclerosis. 2004;177:161–166. doi: 10.1016/j.atherosclerosis.2004.07.003. - DOI - PubMed

Publication types