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Review
. 2024 Dec;5(12):1800-1814.
doi: 10.1038/s43018-024-00854-6. Epub 2024 Dec 13.

How the bone microenvironment shapes the pre-metastatic niche and metastasis

Kailey N Jackett  1 , Alice T Browne  1 , Etan R Aber  1 , Miranda Clements  1 , Rosandra N Kaplan  2
Affiliations
Review

How the bone microenvironment shapes the pre-metastatic niche and metastasis

Kailey N Jackett et al. Nat Cancer. 2024 Dec.

Abstract

The bone is a frequent metastatic site, with changes in the mineralized bone and the bone marrow milieu that can also prime other sites for metastasis by educating progenitor cells to support metastatic spread. Stromal and immune populations cooperatively maintain the organizationally complex bone niches and are dysregulated in the presence of a distant primary tumor and metastatic disease. Interrogating the bone niches that facilitate metastatic spread using innovative technologies holds the potential to aid in preventing metastasis in and mediated by the bone. Here, we review recent advances in bone niche biology and its adaptations in the context of cancer.

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Conflict of interest statement

Competing interests: The authors declare no competing interests.

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