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Randomized Controlled Trial
. 2025 Feb;5(2):320-331.
doi: 10.1038/s43587-024-00775-0. Epub 2024 Dec 13.

The CALERIE Genomic Data Resource

C P Ryan  1 , D L Corcoran  2 , N Banskota  3 , C Eckstein Indik  4 , A Floratos  5   6   7 , R Friedman  6   7 , M S Kobor  8   9   10   11   12 , V B Kraus  13   14   15 , W E Kraus  13   14   15 , J L MacIsaac  10 , M C Orenduff  13   14 , C F Pieper  16 , J P White  13   14   15 , L Ferrucci  3 , S Horvath  17 , K M Huffman  13   14   15 , D W Belsky  18   19
Affiliations
Randomized Controlled Trial

The CALERIE Genomic Data Resource

C P Ryan et al. Nat Aging. 2025 Feb.

Abstract

Caloric restriction (CR) slows biological aging and prolongs healthy lifespan in model organisms. Findings from the CALERIE randomized, controlled trial of long-term CR in healthy, nonobese humans broadly supports a similar pattern of effects in humans. To expand our understanding of the molecular pathways and biological processes underpinning CR effects in humans, we generated a series of genomic datasets from stored biospecimens collected from n = 218 participants during the trial. These data constitute a genomic data resource for a randomized controlled trial of an intervention targeting the biology of aging. Datasets include whole-genome single-nucleotide polymorphism genotypes, and three-timepoint-longitudinal DNA methylation, mRNA and small RNA datasets generated from blood, skeletal muscle and adipose tissue samples (total sample n = 2,327). The CALERIE Genomic Data Resource described in this article is available from the Aging Research Biobank. This multi-tissue, multi-omics, longitudinal data resource has great potential to advance translational geroscience. ClinicalTrials.gov registration: NCT00427193 .

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Conflict of interest statement

Competing interests: D.W.B. and D.L.C. are listed as inventors of the Duke University and University of Otago invention DunedinPACE, which is licensed to TruDiagnostic. D.W.B. is consulting CSO and SAB chair of BellSant and serves on the SAB of the Hooke Clinic. The Regents of the University of California are the sole owner of patents and patent applications directed at epigenetic biomarkers for which S.H. is a named inventor; S.H. is a founder and paid consultant of the non-profit Epigenetic Clock Development Foundation that licenses these patents. S.H. is a Principal Investigator at the Altos Labs, Cambridge Institute of Science, a biomedical company that works on rejuvenation. The remaining authors declare no competing interests.

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