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Review
. 2025 Jan:119:102473.
doi: 10.1016/j.compmedimag.2024.102473. Epub 2024 Dec 5.

A review of the Segment Anything Model (SAM) for medical image analysis: Accomplishments and perspectives

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Review

A review of the Segment Anything Model (SAM) for medical image analysis: Accomplishments and perspectives

Mudassar Ali et al. Comput Med Imaging Graph. 2025 Jan.

Abstract

The purpose of this paper is to provide an overview of the developments that have occurred in the Segment Anything Model (SAM) within the medical image segmentation category over the course of the past year. However, SAM has demonstrated notable achievements in adapting to medical image segmentation tasks through fine-tuning on medical datasets, transitioning from 2D to 3D datasets, and optimizing prompting engineering. This is despite the fact that direct application on medical datasets has shown mixed results. Despite the difficulties, the paper emphasizes the significant potential that SAM possesses in the field of medical segmentation. One of the suggested directions for the future is to investigate the construction of large-scale datasets, to address multi-modal and multi-scale information, to integrate with semi-supervised learning structures, and to extend the application methods of SAM in clinical settings. In addition to making a significant contribution to the field of medical segmentation.

Keywords: Interactive segmentation; Large-scale dataset development; Medical data annotation; Medical image segmentation; Multi-modal image analysis; Prompt engineering; Segmentation Anything Model; Semi-supervised learning; Uncertainty estimation in segmentation and clinical application of AI.

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Conflict of interest statement

Declaration of competing interest This manuscript has not been previously published or submitted to any other journal and will not be submitted elsewhere before a decision is made. All authors have reviewed and agreed to the submission.

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