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. 2024 Dec 13;5(12):1452-1455.
doi: 10.1016/j.medj.2024.10.022.

Depemokimab, the first ultra-long-acting anti-IL-5 monoclonal antibody for severe eosinophilic asthma

Santi Nolasco  1 , Claudia Crimi  2
Affiliations

Depemokimab, the first ultra-long-acting anti-IL-5 monoclonal antibody for severe eosinophilic asthma

Santi Nolasco et al. Med. .

Abstract

Depemokimab, the first ultra-long-acting anti-IL-5 monoclonal antibody, significantly reduced exacerbation rates in patients with severe eosinophilic asthma when administered biannually.1 While it offers potential benefits for patient adherence and convenience, the trials showed no improvement in symptoms and lung function. Further research is needed to determine its optimal place in therapy and identify patients who will benefit the most.

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Conflict of interest statement

Declaration of interests C.C. reports honoraria for lectures from GSK, Sanofi, AstraZeneca, Vitalaire, Fisher & Paykel, ResMed, and Philips, outside the submitted work.

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