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Multicenter Study
. 2025 Mar:278:114440.
doi: 10.1016/j.jpeds.2024.114440. Epub 2024 Dec 12.

Precocious Puberty in Children with Neurofibromatosis Type 1

Julia Katz  1 , Sarayu Ratnam  2 , Robert H Listernick  3 , Reema L Habiby  2 , David H Gutmann  4
Affiliations
Multicenter Study

Precocious Puberty in Children with Neurofibromatosis Type 1

Julia Katz et al. J Pediatr. 2025 Mar.

Abstract

This multi-institutional, descriptive study of 19 children with neurofibromatosis 1 examines the link between optic pathway gliomas (OPGs) and central precocious puberty (CPP). We report that CPP can arise without OPG chiasmal involvement and that prior OPG chemotherapy does not prevent the development of CPP.

Keywords: NF1; neurofibromatosis; optic pathway glioma; precocious puberty.

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Conflict of interest statement

Declaration of Competing Interest There is no grant funding to report. R.H. serves as a speaker for Tolmar Pharmaceuticals. The other authors have no relevant disclosures or conflicts of interest to report.

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