Current investigation of carcinoembryonic antigen cell adhesion molecule (CEACAM) biology summary of the 32nd CEA symposium: 20-23 September 2024. Würzburg, Germany

James M Fleckenstein¹, Sonia M Najjar², Wolfgang Zimmermann³, Christof R Hauck⁴, Quynh Nguyen⁵, Raquel Mejias-Luque⁵, Asima Bhattacharyya⁶, Alex J McCarthy⁷, Arup Sarkar⁶, Maciej Kujawski⁸, Anastasia Konieva⁹, Fadi Elyateem⁹, Irina Kube-Golovin⁹, Gunther Wennemuth⁹, Robert Kammerer¹⁰, Keith M Skubitz¹¹, John E Shively⁸, Kenneth J Dery¹², Gabriela Dveksler¹³, Lisa Götz¹⁴, Florian Kleefeldt¹⁴, Süleyman Ergün¹⁴

Affiliations

¹ Department of Medicine, Washington University in Saint Louis, School of Medicine, Saint Louis, Missouri, USA.
² Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.
³ Ludwig-Maximilians-Universität Munchen, Munich, Germany.
⁴ Universität Konstanz Fachbereich Biologie, Germany.
⁵ Technical University of Munich, Munich, Germany.
⁶ School of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, Bhubaneswar, India.
⁷ Imperial College, London, UK.
⁸ City of Hope, California, USA.
⁹ Universität Duisburg-Essen, Essen, Germany.
¹⁰ Friedrich-Loeffler Institut, Greifswald, Germany.
¹¹ University of Minnesota, Minneapolis, Minnesota, USA.
¹² University of California, California, Los Angeles, USA.
¹³ Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
¹⁴ Julius Maximilians Universität, Würzburg, Germany.

PMID: 39674873
PMCID: PMC11880994
DOI: 10.1111/eci.14355

Current investigation of carcinoembryonic antigen cell adhesion molecule (CEACAM) biology summary of the 32nd CEA symposium: 20-23 September 2024. Würzburg, Germany

James M Fleckenstein et al. Eur J Clin Invest. 2024 Dec.

. 2024 Dec;54 Suppl 2(Suppl 2):e14355.

doi: 10.1111/eci.14355.

Authors

Affiliations

¹ Department of Medicine, Washington University in Saint Louis, School of Medicine, Saint Louis, Missouri, USA.
² Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.
³ Ludwig-Maximilians-Universität Munchen, Munich, Germany.
⁴ Universität Konstanz Fachbereich Biologie, Germany.
⁵ Technical University of Munich, Munich, Germany.
⁶ School of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, Bhubaneswar, India.
⁷ Imperial College, London, UK.
⁸ City of Hope, California, USA.
⁹ Universität Duisburg-Essen, Essen, Germany.
¹⁰ Friedrich-Loeffler Institut, Greifswald, Germany.
¹¹ University of Minnesota, Minneapolis, Minnesota, USA.
¹² University of California, California, Los Angeles, USA.
¹³ Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
¹⁴ Julius Maximilians Universität, Würzburg, Germany.

PMID: 39674873
PMCID: PMC11880994
DOI: 10.1111/eci.14355

No abstract available

Keywords: CEACAM; atherogenesis; cancer; immunity; metabolism; reproduction.

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Conflict of interest statement

Conflict of Interest

This manuscript is part of the special issue entitled “CEACAM in Health and Disease” that is co-edited by SM Najjar, one of the co-authors of this manuscript. All other authors report they have no conflicts of interest. This is an original manuscript and has not been previously published or submitted to another journal.

References

1. Zhuo Y, Yang JY, Moremen KW, Prestegard JH. Glycosylation Alters Dimerization Properties of a Cell-surface Signaling Protein, Carcinoembryonic Antigen-related Cell Adhesion Molecule 1 (CEACAM1). The Journal of biological chemistry. 2016;291(38):20085–20095. - PMC - PubMed
1. Tchoupa AK, Schuhmacher T, Hauck CR. Signaling by epithelial members of the CEACAM family - mucosal docking sites for pathogenic bacteria. Cell Commun Signal. 2014;12:27. - PMC - PubMed
1. Abou-Rjaily GA, Lee SJ, May D, et al. CEACAM1 modulates epidermal growth factor receptor--mediated cell proliferation. The Journal of clinical investigation. 2004;114(7):944–952. - PMC - PubMed
1. Poy MN, Ruch RJ, Fernstrom MA, Okabayashi Y, Najjar SM. Shc and CEACAM1 interact to regulate the mitogenic action of insulin. The Journal of biological chemistry. 2002;277(2):1076–1084. - PubMed
1. Schmitter T, Agerer F, Peterson L, Munzner P, Hauck CR. Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens. J Exp Med. 2004;199(1):35–46. - PMC - PubMed

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Current investigation of carcinoembryonic antigen cell adhesion molecule (CEACAM) biology summary of the 32nd CEA symposium: 20-23 September 2024. Würzburg, Germany

Affiliations

Current investigation of carcinoembryonic antigen cell adhesion molecule (CEACAM) biology summary of the 32nd CEA symposium: 20-23 September 2024. Würzburg, Germany

Authors

Affiliations

Conflict of interest statement

References

Grants and funding

LinkOut - more resources

Full Text Sources