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. 1985 Feb;156(2):553-7.
doi: 10.1016/0014-4827(85)90562-2.

DNA-mediated transfer of actinomycin D resistance into cultured mouse cells

H G Suárez, P C Nardeux, M Barbich

DNA-mediated transfer of actinomycin D resistance into cultured mouse cells

H G Suárez et al. Exp Cell Res. 1985 Feb.

Abstract

The transfer of high molecular weight (HMW) DNA isolated from Syrian hamster actinomycin D-resistant cells (C12TSV5/R) to sensitive A9 mouse cells, resulted in the growth in selective medium of transferent clones A9 ActR C11, C12 and C13). The resistant mouse cells have presumably acquired a gene(s) conferring actinomycin D resistance and express a 140-150 K surface glycoprotein, apparently involved in the drug resistance.

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