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. 2024 Nov 14;16(11):e73661.
doi: 10.7759/cureus.73661. eCollection 2024 Nov.

Prevalence of Vitamin D Deficiency and Its Association With Anthropometric and Hematological Parameters Among Infants at a Tertiary Care Center in Meerut, India: A Cross-Sectional Study

Uday K Mandal  1 , Ajeet Kumar Yadav  2 , Mayukh Mukherjee  3 , Ram K Nema  4 , Hemant S Thakur  1 , Vikas Yadav  1 , Yogesh D Sabde  1
Affiliations

Prevalence of Vitamin D Deficiency and Its Association With Anthropometric and Hematological Parameters Among Infants at a Tertiary Care Center in Meerut, India: A Cross-Sectional Study

Uday K Mandal et al. Cureus. .

Abstract

Introduction: Vitamin D is crucial in calcium homeostasis and bone metabolism, and its deficiency is widespread even in sun-rich regions like India. The present study sought to elucidate the prevalence of vitamin D deficiency in infants and its potential association with various anthropometric and hematological parameters.

Methods: The study was conducted in a tertiary care hospital in northern India (in 2013-14) and involved 77 nine-month-old infants. Data collection included demographic information, anthropometric measurements, and laboratory parameters like levels of serum vitamin D, intact parathyroid hormone (iPTH), calcium, phosphorus, alkaline phosphatase (ALP), hemoglobin (Hb), packed cell volume (PCV), total RBC count, and mean corpuscular volume (MCV). Vitamin D status was classified based on serum 25-hydroxyvitamin D [25(OH) D] levels.

Results: The prevalence of vitamin D deficiency was 42.9% (33 out of 77 infants). Infants with vitamin D deficiency had significantly lower mean body weight (8.26 ± 0.89 kg) as compared to vitamin D non-deficient infants (8.72 ± 0.99 kg) (p = 0.04). Hematological analysis revealed significantly lower Hb levels (9.59 ± 1.68 g/dL) in the vitamin D deficient group compared to the vitamin D non-deficient group (10.35 ± 1.44 g/dL) (p = 0.04). Other significant differences included lower PCV (p = 0.03) and MCV (p = 0.002) in the vitamin D-deficient group.

Conclusion: This study highlights the high prevalence of vitamin D deficiency (42.9%) among infants and its significant association (p-value less than 0.05) with reduced body weight and hematological indices like Hb, PCV, and MCV. These findings underscore the need for routine screening, nutritional interventions, and vitamin D supplementation to address vitamin D deficiency among infants. Further research involving diverse populations is required to validate these results, further guiding optimum public health strategies.

Keywords: anthropometric indices; cross-sectional study; hematological parameters; infants; northern india; vitamin d deficiency.

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Conflict of interest statement

Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. L.L.R.M Medical College Ethical Committee issued approval -. Ethically approved by the institutional ethical committee meeting. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

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References

    1. The role of vitamin D in the endocrinology controlling calcium homeostasis. Fleet JC. Mol Cell Endocrinol. 2017;453:36–45. - PMC - PubMed
    1. Sunshine exposure and serum 25-hydroxyvitamin D concentrations in exclusively breast-fed infants. Specker BL, Valanis B, Hertzberg V, Edwards N, Tsang RC. J Pediatr. 1985;107:372–376. - PubMed
    1. Vitamin D deficiency in breastfed infants in Iowa. Ziegler EE, Hollis BW, Nelson SE, Jeter JM. Pediatrics. 2006;118:603–610. - PubMed
    1. Prevalence and correlates of vitamin D deficiency among children and adolescents from a nationally representative survey in India. Rana G, Abraham RA, Sachdev HS, et al. https://www.indianpediatrics.net/mar2023/202.pdf. Indian Pediatr. 2023;60:202–206. - PubMed
    1. Establishing the prevalence of osteomalacia in Arab adolescents using biochemical markers of bone health. Al-Daghri NM, Yakout S, Sabico S, et al. Nutrients. 2022;14:5354. - PMC - PubMed

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