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Case Reports
. 2024 Nov 29:14:1437535.
doi: 10.3389/fonc.2024.1437535. eCollection 2024.

Case report: A case of giant malignant solitary fibrous tumor of the pleura with Doege-Potter's syndrome and review of the literature

Jie Li  1 , Hong-Tao Tang  2 , Qing Liu  1   3 , Cai-Han Li  4 , Wei-Yang Chen  5 , Zeng-Wei Yu  1 , Lei Wang  1 , Lin Lin  1 , Jin-Lan Zhao  6 , Chun-Yan Zhao  7 , Long-Qi Chen  1 , Dong Tian  1
Affiliations
Case Reports

Case report: A case of giant malignant solitary fibrous tumor of the pleura with Doege-Potter's syndrome and review of the literature

Jie Li et al. Front Oncol. .

Abstract

The solitary fibrous tumor of the pleura (SFTP) is a rare intrathoracic neoplasm that commonly originates from the subpleural mesenchymal cells of the visceral pleura and accounts for less than 5% of all pleural tumors. We reported a case of a 54-year-old man with a two-week history of hypoglycemia, a six-month history of productive cough and fatigue, and chronic right chest pain. Radiological techniques revealed a giant intra-thoracic mass with hypervascularization, and pathological staining was carried out to make a definitive diagnosis of SFTP. Interventional embolization was conducted to block the main feeding vessels before the surgery, and an anterolateral thoracotomy combined with a transverse sternotomy was performed to achieve a complete resection, which demonstrates significant potential for further application in patients with unilateral giant SFTP. The postoperative course was uneventful, with no signs of hypoglycemia observed during the follow-up. Additionally, we reviewed and prospected the research progress on SFTP. The aim of this study is to enhance clinicians' understanding of SFTP through our case and to provide a detailed review of the current research.

Keywords: Doege-Potter’s syndrome; hypoglycemia; malignant lesion; solitary fibrous tumor of the pleura; surgical approach; surgical resection.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The contrast-enhanced chest CT showed a giant intra-thoracic heterogeneous mass occupying the right chest cavity (A). The CT angiography reconstruction revealed hypervascularization (B). The contrast-enhanced MRI presented uneven enhancement within the tumor (C). CT, computed tomography; MRI, magnetic resonance imaging.
Figure 2
Figure 2
Histopathological views of SFTP. The low-power (10×) hematoxylin and eosin (H&E) view showed a patternless pattern (A), and the high-power (40×) H&E view showed enlarged spindle cells with a variable proportion of collagenous stroma (B). The tumor cells were also positive for CD34 (C) and STAT6 (D).
Figure 3
Figure 3
Pre- and post-embolization images of a feeding vessel originating from the bronchial artery.
Figure 4
Figure 4
Anterolateral thoracotomy combined with transverse sternotomy (A) and the macroscopic view of the resected giant tumor and right lung (B).
See this image and copyright information in PMC

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