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. 2024 Dec;13(24):e70494.
doi: 10.1002/cam4.70494.

Assessment and Prediction of Salivary Gland Function After Head and Neck Radiotherapy: A Systematic Review

J Le Guevelou  1 , X Palard-Novello  2 , E Kammerer  1 , M Baty  1 , M Perazzi  1 , A Larnaudie  3 , R De Crevoisier  1 , J Castelli  1
Affiliations

Assessment and Prediction of Salivary Gland Function After Head and Neck Radiotherapy: A Systematic Review

J Le Guevelou et al. Cancer Med. 2024 Dec.

Abstract

Background: Modern imaging techniques with magnetic resonance imaging (MRI) or positron emission tomography/computed tomography (PET/CT) have recently been developed to assess radiation-induced damage to salivary structures. The primary aim of this review was to summarize evidence on the imaging modalities used for the assessment and prediction of xerostomia after head and neck radiotherapy (RT).

Methods: A systematic review of the literature was performed using successively the MeSH terms "PET," "MRI," "scintigraphy," "xerostomia," and "radiotherapy."

Results: Salivary excretion flow following head and neck RT is correlated with the dose delivered to both parotid and submandibular glands. Salivary gland standardized uptake value extracted from PET/CT following RT has been shown to be correlated with SEF. Models including early SUV decline or ADC increase during RT and clinical parameters can help predict the loss of salivary function after RT.

Conclusions: Modern imaging parameters appear to be correlated with salivary gland scintigraphy parameters. Models including functional parameters extracted from either PET/CT or MRI unveil new possibilities for adaptive treatment in a selected population of patients.

Keywords: MRI; PET/CT; head and neck cancer; radiotherapy; salivary gland; xerostomia.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Flowchart of the study.
FIGURE 2
FIGURE 2
Correlation between the different imaging modalities and dose‐volume parameters (mean dose, volume receiving XGy, etc.)/onset of xerostomia. Full line: Existence of a correlation, dotted line: Doubtful correlation. ADC = apparent diffusion coefficient, Gy = gray, PET/CT = positron emission tomography/computed tomography, SEF = salivary excretion function, SGS = salivary gland scintigraphy, SUV = standardized uptake value, TTP = time to peak.
See this image and copyright information in PMC

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