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. 2025 May;22(5):e202403120.
doi: 10.1002/cbdv.202403120. Epub 2025 Jan 7.

New Arylalkenyl α-Pyrones from Cryptocarya densiflora

Jie Meng  1   2   3 , Jun-Juan Xue  4 , Lei Miao  1 , Yu Zhang  1 , Li Rao  3 , Chuan-Rui Zhang  1   2   3   5
Affiliations

New Arylalkenyl α-Pyrones from Cryptocarya densiflora

Jie Meng et al. Chem Biodivers. 2025 May.

Abstract

Four previously undescribed arylalkenyl α-pyrones, designated as crydensiones A‒D (1‒4), were isolated from the twigs and leaves of Cryptocarya densiflora. Their structures were determined through comprehensive spectroscopic analyses together with quantum chemical calculations of electronic circular dichroism and nuclear magnetic resonance data. All isolates were assessed for cytotoxicity against HCT-116 (colon), A549 (lung), and MDA-MB-231 (breast) cancer cell lines; however, none demonstrated significant activity.

Keywords: Cryptocarya densiflora; cytotoxicity; quantum chemical calculations; spectroscopic data; α‐pyrones.

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References

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