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Review
. 2025:73:581-607.
doi: 10.1007/7854_2024_558.

Fear and Anxiety in Schizophrenia: A Focus on Development, Assessment, and Mechanisms

Brandee Feola  1 , Marren Jenkins  2 , Julia M Sheffield  2 , Jennifer Urbano Blackford  3   2
Affiliations
Review

Fear and Anxiety in Schizophrenia: A Focus on Development, Assessment, and Mechanisms

Brandee Feola et al. Curr Top Behav Neurosci. 2025.

Abstract

In people with schizophrenia, anxiety is highly prevalent and related to numerous negative outcomes; unfortunately, anxiety is both underreported and understudied in schizophrenia. The current review highlights the importance and utility of assessing anxiety in schizophrenia by addressing four main questions: (1) What does anxiety look like throughout the development of schizophrenia?; (2) How do we measure anxiety in schizophrenia?; (3) What are the mechanisms underlying anxiety in schizophrenia; (4) How do we treat anxiety in schizophrenia? We also provide take-home points and propose future directions for the field. We hope this emphasis on the critical role of anxiety in schizophrenia will help researchers appropriately identify the presence of anxiety, better address these symptoms, and improve the lives of people at risk for or experiencing psychosis.

Keywords: Anxiety disorders; Negative affect; Negative emotion; Psychosis; Schizophrenia spectrum disorders.

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References

    1. Shioiri T, Shinada K, Kuwabara H, Someya T. Early prodromal symptoms and diagnoses before first psychotic episode in 219 inpatients with schizophrenia. Psychiatry Clin Neurosci. 2007;61(4):348–354. doi: 10.1111/j.1440-1819.2007.01685.x - DOI - PubMed
    1. Strålin P, Hetta J. First episode psychosis: register-based study of comorbid psychiatric disorders and medications before and after. Eur Arch Psychiatry Clin Neurosci. 2021;271(2):303–313. doi: 10.1007/s00406-020-01139-6 - DOI - PMC - PubMed
    1. Mulugeta A, Suppiah V, Hyppönen E. Schizophrenia and co-morbidity risk: Evidence from a data driven phenomewide association study. J Psychiatr Res. 2023;162:1–10. doi: 10.1016/j.jpsychires.2023.04.010 - DOI - PubMed
    1. Achim AM, Maziade M, Raymond É, Olivier D, Mérette C, Roy MA. How prevalent are anxiety disorders in schizophrenia? a meta-analysis and critical review on a significant association. Schizophr Bull. 2011;37(4):811–821. doi: 10.1093/schbul/sbp148 - DOI - PMC - PubMed
    1. Michail M, Birchwood M. Social anxiety disorder in first-episode psychosis: Incidence, phenomenology and relationship with paranoia. British Journal of Psychiatry. 2009;195(3):234–241. doi: 10.1192/bjp.bp.108.053124 - DOI - PubMed