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Review
. 2024 Dec 16;20(1):2.
doi: 10.1007/s11899-024-00745-8.

Monoclonal Gammopathy-Associated Neuropathy

Shayna Sarosiek  1   2 , Christopher T Doughty  3   4 , Jorge J Castillo  5   4
Affiliations
Review

Monoclonal Gammopathy-Associated Neuropathy

Shayna Sarosiek et al. Curr Hematol Malig Rep. .

Abstract

Purpose of review: Peripheral neuropathy (PN) is more commonly seen in individuals with monoclonal gammopathies, especially in patients with an IgM monoclonal gammopathy or Waldenström macroglobulinemia.

Recent findings: There are multiple potential ways that the paraprotein may result in peripheral neuropathy. The diagnosis and management of monoclonal gammopathy-associated PN are challenging and necessitate a concerted effort between the hematologist/oncologist and the neurologist. This review describes the most common PN syndromes associated with monoclonal gammopathy, such as anti-myelin-associated glycoprotein neuropathy, light chain amyloidosis, cryoglobulinemia, POEMS, CANOMAD, and others. We also review the therapies used to treat these conditions.

Keywords: Amyloidosis; Anti-MAG; CANOMAD; Cryoglobulinemia; Monoclonal gammopathy; Neuropathy; POEMS; Waldenström macroglobulinemia.

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Conflict of interest statement

Declarations. Conflict of Interest: SS received research funds or honoraria from Beigene, Cellectar, and ADC Therapeutics. CTD received research funds from AstraZeneca and honoraria from Argenx, UCB, and TD Cowen. JJC received research funds or honoraria from Abbvie, AstraZeneca, Beigene, Cellectar, Janssen, Kite, Loxo, and Pharmacyclics. Human and Animal Rights and Informed Consent: This article does not contain any studies with human or animal subjects performed by any of the authors.

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