Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Dec 2;16(23):4048.
doi: 10.3390/cancers16234048.

Genetic Blueprints in Lung Cancer: Foundations for Targeted Therapies

Andra Dan  1 , Livia-Malina Burtavel  1 , Madalin-Codrut Coman  1 , Ina-Ofelia Focsa  1 , Simona Duta-Ion  1 , Ioana-Ruxandra Juganaru  1 , Andra-Giorgiana Zaruha  1 , Patricia-Christina Codreanu  1 , Irina-Maria Strugari  1 , Iulian-Andrei Hotinceanu  1 , Laurentiu-Camil Bohiltea  1   2 , Viorica-Elena Radoi  1   2
Affiliations
Review

Genetic Blueprints in Lung Cancer: Foundations for Targeted Therapies

Andra Dan et al. Cancers (Basel). .

Abstract

Lung cancer, a malignant neoplasm originating from the epithelial cells of the lung, is characterized by its aggressive growth and poor prognosis, making it a leading cause of cancer-related mortality globally [...].

Keywords: NSCLC; SCLC; alterations; biomarkers; diagnosis; genetics; lung cancer; pathways; personalized medicine; therapies.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Classification of lung cancers.
Figure 2
Figure 2
Lung cancer predisposition syndromes.
Figure 3
Figure 3
Genes involved in lung carcinogenesis.
Figure 4
Figure 4
The MAPK pathway.
Figure 5
Figure 5
The JAK-STAT pathway.
Figure 6
Figure 6
The LKB1/AMPK/mTOR pathway.
Figure 7
Figure 7
The EGFR/PI3K/Akt/mTOR pathway.
Figure 8
Figure 8
The Keap1-Nrf2 pathway.
Figure 9
Figure 9
The Wnt/β-catenin pathway.
Figure 10
Figure 10
The VEGF/VEGFR pathway.
Figure 11
Figure 11
The NF-κB pathway.
Figure 12
Figure 12
The PD-1/PD-L1 pathway in lung cancer.
Figure 13
Figure 13
The apoptosis pathway.
Figure 14
Figure 14
The hypoxia-induced pathway.
Figure 15
Figure 15
Notch pathway.
Figure 16
Figure 16
Benefits and risks of genetic testing.
See this image and copyright information in PMC

References

    1. Kanwal M., Ding X.J., Cao Y. Familial risk for lung cancer. Oncol. Lett. 2017;13:535–542. doi: 10.3892/ol.2016.5518. - DOI - PMC - PubMed
    1. Sung H., Ferlay J., Siegel R.L., Laversanne M., Soerjomataram I., Jemal A., Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J. Clin. 2021;71:209–249. doi: 10.3322/caac.21660. - DOI - PubMed
    1. [(accessed on 28 August 2024)]. Available online: https://ec.europa.eu/eurostat/statistics-explained/index.php?title=Cance....
    1. Powell H.A., Iyen-Omofoman B., Hubbard R.B., Baldwin D.R., Tata L.J. The association between smoking quantity and lung cancer in men and women. Chest. 2013;143:123–129. doi: 10.1378/chest.12-1068. - DOI - PubMed
    1. Araghi M., Mannani R., Heidarnejad Maleki A., Hamidi A., Rostami S., Safa S.H., Faramarzi F., Khorasani S., Alimohammadi M., Tahmasebi S., et al. Recent Advances in Non-Small Cell Lung Cancer Targeted Therapy; an Update Review. Cancer Cell Int. 2023;23:162. doi: 10.1186/s12935-023-02990-y. - DOI - PMC - PubMed

LinkOut - more resources