Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Nov 21;16(23):3983.
doi: 10.3390/nu16233983.

Prevalence, Risk Factors and Association with Clinical Outcomes of Malnutrition and Sarcopenia in Inflammatory Bowel Disease: A Prospective Study

Cristina Bezzio  1   2 , Daniele Brinch  3 , Davide Giuseppe Ribaldone  4 , Maria Cappello  5 , Natalie Ruzzon  3 , Marta Vernero  4 , Davide Scalvini  6 , Laura Loy  1 , Sofia Donghi  3 , Stefania Ciminnisi  5 , Gianpiero Manes  3 , Alessandro Armuzzi  1   2 , Simone Saibeni  3
Affiliations

Prevalence, Risk Factors and Association with Clinical Outcomes of Malnutrition and Sarcopenia in Inflammatory Bowel Disease: A Prospective Study

Cristina Bezzio et al. Nutrients. .

Abstract

Introduction: The prevalences of malnutrition and sarcopenia in patients with IBD are not precisely known, and nutritional assessment is not standardized. We assessed the prevalence and risk factors of these conditions in outpatients and their impact on clinical outcomes.

Methods: This prospective longitudinal study considered patients who had IBD for at least one year, were attending a tertiary IBD center, and were followed for the subsequent year.

Results: In a sample of 158 consecutive patients (96 with Crohn's disease and 62 with ulcerative colitis), the prevalence of malnutrition, according to GLIM criteria, was 13.3%. For identifying patients at risk of malnutrition, the Malnutrition Universal Screening Tool demonstrated better accuracy, (sensitivity 88.9 (65.3-98.6) and specificity 90.2 (83.8-93.4)) than the SaskIBD-NR questionnaire (sensitivity 69.3 (41.1-86.7) and specificity 60.9 (60.9-76.8)). The prevalence of sarcopenia was 34.2%. Considering clinical outcomes, sarcopenia at baseline was significantly associated with hospital admission within a year (p = 45.2% vs. 20.3%, 0.026).

Conclusions: Malnutrition and sarcopenia were present in about one-third of IBD patients. Awareness should be raised among physicians caring for IBD patients about the need to evaluate patients' nutritional statuses to help patients achieve a better quality of life.

Keywords: Crohn; GLIM; MUST; SaskIBD; ulcerative colitis.

PubMed Disclaimer

Conflict of interest statement

C.B. served as a consultant or received lecture fees from AbbVie, Alfasigma, Celltrion, Eli Lilly, Ferring, Fresenius Kabi, Galapagos, Lionhealth, Johnson & Johnson, MSD, Pfizer, and Takeda. S.S. received lecture fees from Janssen Pharmaceuticals and Takeda Pharmaceuticals and served as a consultant and advisory board member for AbbVie and Janssen Pharmaceuticals. D.G.R. received fees for consultancies from Biogen, Celltrion, Galapagos, Janssen, and Takeda. M.C. has received lecture fees and served as an Advisory Board Member for AbbVie, Biogen, Ferring, Galapagos, Janssen, Kedrion, Takeda, and Pfizer. M.V. received lecture fees from Abbvie, Takeda, and AgPharma. L.L. and D.G.R. received fees for consultancies from Celltrion, Galapagos, Janssen, and Takeda. The other authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Correlation between MUST and Sask IBD in determining the risk of malnutrition. The circles in the graph represent integer numbers.
Figure 2
Figure 2
Receiver operating characteristic (ROC) curves to determine threshold values for predicting malnutrition. (A) MUST scores. (B) SaskIBD-NR scores. (C) Waist circumference for female patients. (D) Waist circumference for male patients.
Figure 3
Figure 3
Association between presence of malnutrition (A) and sarcopenia (B) and negative outcomes within a year.
See this image and copyright information in PMC

References

    1. Wellcome Trust Case Control Consortium Genome-wide association study of 14,000 cases of seven common diseases and 3000 shared controls. Nature. 2007;447:661–678. doi: 10.1038/nature05911. - DOI - PMC - PubMed
    1. Franke A., Balschun T., Karlsen T.H., Sventoraityte J., Nikolaus S., Mayr G., Domingues F.S., Albrecht M., Nothnagel M., Ellinghaus D., et al. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat. Genet. 2008;40:1319–1323. doi: 10.1038/ng.221. - DOI - PubMed
    1. Rioux J.D., Xavier R.J., Taylor K.D., Silverberg M.S., Goyette P., Huett A., Green T., Kuballa P., Barmada M.M., Datta L.W., et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat. Genet. 2007;39:596–604. doi: 10.1038/ng2032. - DOI - PMC - PubMed
    1. Rao S.S., Holdsworth C.D., Read N.W. Symptoms and stool patterns in patients with ulcerative colitis. Gut. 1988;29:342–345. doi: 10.1136/gut.29.3.342. - DOI - PMC - PubMed
    1. Lennard-Jones J.E., Shivananda S. Clinical uniformity of inflammatory bowel disease a presentation and during the first year of disease in the north and south of Europe. EC-IBD Study Group. Eur. J. Gastroenterol. Hepatol. 1997;9:353–359. doi: 10.1097/00042737-199704000-00007. - DOI - PubMed

LinkOut - more resources