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. 2024 Nov 29;16(23):4132.
doi: 10.3390/nu16234132.

The Interconnection Between Systemic Lupus Erythematosus and Diet: Unmet Needs, Available Evidence, and Guidance-A Patient-Driven, Multistep-Approach Study

Savino Sciascia  1 , Gabriele Ferrara  1 , Lorenzo Roccatello  1 , Elena Rubini  1 , Silvia Grazietta Foddai  1 , Massimo Radin  1 , Irene Cecchi  1 , Daniela Rossi  1 , Alice Barinotti  1 , Fulvio Ricceri  2 , Winston Gilcrease  2 , Simone Baldovino  1 , Andrea Ferreira Poshar  1 , Alessio Conti  1 , Roberta Fenoglio  1
Affiliations

The Interconnection Between Systemic Lupus Erythematosus and Diet: Unmet Needs, Available Evidence, and Guidance-A Patient-Driven, Multistep-Approach Study

Savino Sciascia et al. Nutrients. .

Abstract

Background/objectives: Inflammation and immunological dysregulation are central to systemic lupus erythematosus (SLE), a complex autoimmune disease. Recently, there has been increasing interest in the potential role of dietary factors in SLE. This study aimed to explore the relationship between diet and SLE by addressing patient needs, conducting a systematic review, and providing guidance to the patient community.

Methods: This four-step study started with a survey of patients with SLE that was conducted to gather frequently asked questions (FAQs) related to diet. Using the PICO framework, two comprehensive systematic literature searches were performed in PubMed to address these FAQs. Subsequently, the evidence retrieved was used to answer FAQs and provide guidance to people with SLE. A second survey was conducted to gather patient feedback on the topics and guidance provided.

Results: A literature review of 28 systematic reviews was performed, evaluating the impact of diet on inflammation, immune response, and health outcomes in SLE patients. The review focused on key nutritional elements, including vitamin D, omega-3 fatty acids, curcumin supplements, and low-calorie or low-glycemic index diets. Seven guidance statements were developed based on these findings. All the answers provided were positively assessed by participants.

Conclusions: This patient-centered study improves our understanding of the diet-SLE relationship through systematic reviews and patient feedback. While specific dietary recommendations for SLE are not yet established, patient input underscores the need for ongoing research to optimize treatment strategies and quality of life for those with SLE.

Keywords: diet; patient-driven research; supplements; systemic lupus erythematosus.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Visual representation of the four-step study design.
Figure 2
Figure 2
Literature review process.
Figure 3
Figure 3
Spider chart summarizing the Likert ratings for all the proposed statements.
See this image and copyright information in PMC

References

    1. Hoi A., Igel T., Mok C.C., Arnaud L. Systemic Lupus Erythematosus. Lancet. 2024;403:2326–2338. doi: 10.1016/S0140-6736(24)00398-2. - DOI - PubMed
    1. Alarcón G.S., McGwin G., Petri M., Reveille J.D., Ramsey-Goldman R., Kimberly R.P. Baseline Characteristics of a Multiethnic Lupus Cohort: PROFILE. Lupus. 2002;11:95–101. doi: 10.1191/9612332lu155oa. - DOI - PubMed
    1. Pesqueda-Cendejas K., Campos-López B., Mora-García P.E., Moreno-Ortiz J.M., De la Cruz-Mosso U. Methyl Donor Micronutrients: A Potential Dietary Epigenetic Target in Systemic Lupus Erythematosus Patients. Int. J. Mol. Sci. 2023;24:3171. doi: 10.3390/ijms24043171. - DOI - PMC - PubMed
    1. Mok C.C., Lau C.S. Pathogenesis of Systemic Lupus Erythematosus. J. Clin. Pathol. 2003;56:481–490. doi: 10.1136/jcp.56.7.481. - DOI - PMC - PubMed
    1. Somers E.C., Richardson B.C. Environmental Exposures, Epigenetic Changes and the Risk of Lupus. Lupus. 2014;23:568–576. doi: 10.1177/0961203313499419. - DOI - PMC - PubMed

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