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. 2024 Nov 30;16(23):4164.
doi: 10.3390/nu16234164.

The Mediating Role of Body Mass Index in the Association Between Dietary Index for Gut Microbiota and Biological Age: A Study Based on NHANES 2007-2018

Shuli An  1 , Jian Qin  1 , Xinjie Gong  1 , Shuangshuang Li  1 , Haiyan Ding  1 , Xue Zhao  1 , Hongqi He  1 , Linwei Zhou  1 , Xinrui Deng  2 , Xia Chu  1
Affiliations

The Mediating Role of Body Mass Index in the Association Between Dietary Index for Gut Microbiota and Biological Age: A Study Based on NHANES 2007-2018

Shuli An et al. Nutrients. .

Abstract

Objective: The dietary index for gut microbiota (DI-GM) is a newly proposed metric for assessing diet quality, and its relationship with biological age is unclear. We hypothesize that consuming foods conducive to a healthy gut microbiota environment may decelerate aging.

Methods: This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2007 to 2018. The DI-GM was calculated by averaging the intakes from two 24-h dietary recall interviews. The biological age indicators were assessed using the Klemera-Doubal Method (KDM), phenotypic age (PA), and homeostasis disorder (HD). Logistic regression, restricted cubic splines (RCS), and mediation analysis were employed to explore the association between DI-GM and KDM, PA, and HD.

Results: The study included 20,671 participants. According to the logistic regression model, adjusting for all covariates, a negative association was observed between the DI-GM score and biomarkers of biological aging. Compared to participants in the lowest quartile for DI-GM scores, those in the highest quartile exhibited reduced odds ratio (OR) for all of the biological age indicators, namely biological age assessed via KDM (OR: 0.69, 95% CI: 0.60-0.79), PA (OR: 0.84, 95% CI: 0.73-0.97), and HD (OR: 0.86, 95% CI: 0.76-0.98). Additionally, RCS analysis revealed a nonlinear association between DI-GM and biological age. Mediation analysis showed that the body mass index (BMI) partly mediated the association between DI-GM and biological age.

Conclusions: Therefore, we concluded that a higher DI-GM score is associated with a lower risk of accelerated aging, with BMI mediating this association. Future research should validate these findings through the use of longitudinal studies.

Keywords: NHANES; biological age; body mass index; diet; gut microbiota; mediation.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart of participant selection.
Figure 2
Figure 2
Association between DI-GM and biological age by logistic regression.
Figure 3
Figure 3
Association between DI-GM and biological age by RCS.
Figure 4
Figure 4
Association of DI-GM and biological age mediated by BMI.
Figure 5
Figure 5
Stratified analysis of the association between DI-GM and biological age.
See this image and copyright information in PMC

References

    1. Wen L., Jia W., Miao W., Huimin H., Xin D., Lingzhi M., Ming L. Oxidative Stress Factors Mediate the Association Between Life’s Essential 8 and Accelerated Phenotypic Aging: NHANES 2005–2018. J. Gerontol. Ser. A Biol. Sci. Med. Sci. 2024;79:glad240. doi: 10.1093/gerona/glad240. - DOI - PubMed
    1. Wang X., Sarker S.K., Cheng L., Dang K., Hu J., Pan S., Zhang J., Xu X., Li Y. Association of dietary inflammatory potential, dietary oxidative balance score and biological aging. Clin. Nutr. 2024;43:1–10. doi: 10.1016/j.clnu.2023.11.007. - DOI - PubMed
    1. Chen Y., Zheng X., Wang Y., Liu C., Shi J., Liu T., Lin S., Xie H., Zhang H., Liu X., et al. Association between dietary quality and accelerated aging: A cross-sectional study of two cohorts. Food Funct. 2024;15:7837–7848. doi: 10.1039/D4FO02360A. - DOI - PubMed
    1. Zhang R., Wu M., Zhang W., Liu X., Pu J., Wei T., Zhu Z., Tang Z., Wei N., Liu B., et al. Association between life’s essential 8 and biological ageing among US adults. J. Transl. Med. 2023;21:622. doi: 10.1186/s12967-023-04495-8. - DOI - PMC - PubMed
    1. Johnstone S.E., Gladyshev V.N., Aryee M.J., Bernstein B.E. Epigenetic clocks, aging, and cancer. Science. 2022;378:1276–1277. doi: 10.1126/science.abn4009. - DOI - PubMed

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