Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Dec 6;16(23):3429.
doi: 10.3390/polym16233429.

Collagen-Based Scaffolds for Volumetric Muscle Loss Regeneration

Anna L Luss  1 , Maria M Bobrova  1 , Pavel P Kulikov  1 , Anton A Keskinov  1
Affiliations
Review

Collagen-Based Scaffolds for Volumetric Muscle Loss Regeneration

Anna L Luss et al. Polymers (Basel). .

Abstract

Volumetric muscle loss (VML) is a serious problem in healthcare that requires innovative solutions. Collagen and its derivatives are promising biomaterials for muscle tissue replacement due to their high biocompatibility, biodegradability, and lack of toxicity. This review comprehensively discusses collagen from various sources, its structural characteristics, cross-linking methods to obtain hydrogels, and approaches to incorporating various therapeutic molecules to create a biocomposite system with controlled release. Collagen-based scaffolds are promising constructs in tissue engineering and regenerative medicine. They can both perform their function independently and act as a depot for various biologically active substances (drugs, growth factors, genetic material, etc.). Collagen-based scaffolds for muscle volume restoration are three-dimensional constructs that support cell adhesion and proliferation and provide controlled release of therapeutic molecules. Various mechanical and biological properties of scaffolds can be achieved by cross-linking agents and bioactive molecules incorporated into the structure. This review highlights recent studies on collagen-based hydrogels for restoration of volumetric muscle loss.

Keywords: collagen; hydrogel; regeneration; scaffold; tissue engineering.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Application of collagen-based scaffolds.
Figure 2
Figure 2
Amino acid content of human collagen.
Figure 3
Figure 3
Structure of collagen fibers.
Figure 4
Figure 4
Hydrogel fundamental properties for tissue regeneration.
Figure 5
Figure 5
Most used collagen cross-linkers.
Figure 6
Figure 6
Structural formulas of (A)—DMS; (B)—DTBP.
Figure 7
Figure 7
Structure of tannic acid.
Figure 8
Figure 8
Different types of bioactive molecules that could be incorporated into collagen scaffolds.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Alarcin E., Bal-Öztürk A., Avci H., Ghorbanpoor H., Guzel F.D., Akpek A., Yeslitas G., Canak-Ipek T., Avci-Adali M. Current Strategies for the Regeneration of Skeletal Muscle Tissue. Int. J. Mol. Sci. 2021;22:5929. doi: 10.3390/ijms22115929. - DOI - PMC - PubMed
    1. Qazi T.H., Mooney D.J., Pumberger M., Geißler S., Duda G.N. Biomaterials based strategies for skeletal muscle tissue engineering: Existing technologies and future trends. Biomaterials. 2015;53:502–521. doi: 10.1016/j.biomaterials.2015.02.110. - DOI - PubMed
    1. Yang J., Kelly R., Daood M., Ontell M., Watchko J., Ontell M. Alteration in myosatellite cell commitment with muscle maturation. Dev. Dyn. 1998;211:141–152. doi: 10.1002/(SICI)1097-0177(199802)211:2<141::AID-AJA3>3.0.CO;2-H. - DOI - PubMed
    1. Forcina L., Miano C., Pelosi L., Musarò A. An Overview about the Biology of Skeletal Muscle Satellite Cells. Curr. Genom. 2019;20:24–37. doi: 10.2174/1389202920666190116094736. - DOI - PMC - PubMed
    1. Murach K.A., Fry C.S., Dupont-Versteegden E.E., McCarthy J.J., Peterson C.A. Fusion and beyond: Satellite cell contributions to loading-induced skeletal muscle adaptation. FASEB J. 2021;35:e21893. doi: 10.1096/fj.202101096R. - DOI - PMC - PubMed

LinkOut - more resources