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. 2024 Dec 8;13(23):7466.
doi: 10.3390/jcm13237466.

Implications of Preoperative C-Reactive Protein Levels in Heart Transplant Patients-A Single-Center Retrospective Study

Laurentiu Huma  1   2   3 , Horatiu Suciu  2   4 , Calin Avram  5 , Radu-Adrian Suteu  2 , Alina Danilesco  6 , Dragos-Florin Baba  1   2 , Diana-Andreea Moldovan  2   3   7 , Anca-Ileana Sin  1
Affiliations

Implications of Preoperative C-Reactive Protein Levels in Heart Transplant Patients-A Single-Center Retrospective Study

Laurentiu Huma et al. J Clin Med. .

Abstract

Background: Heart transplant is the final therapeutic option for end-stage heart failure patients. It has been used with increasing success as a surgical procedure, greatly influenced by advances in diagnostic and prognostic tools. The aim of this paper was to study potential implications of C-reactive protein (CRP) in patients who underwent heart transplants. Methods: Our cohort included 43 adult patients from the Emergency Institute for Cardiovascular Diseases and Transplant of Târgu Mureș who underwent heart transplants in our center between 2011 and 2023. Correlations between CRP levels and different characteristics of the patients were investigated, and the optimal cut-off value for CRP levels in relation to the 6-month mortality rate was determined. The central tendencies of the baseline characteristics of patients who had a CRP value lower than the cut-off and those with a value higher than it were compared using parametric or nonparametric tests. Results: Significant correlations between the preoperative CRP levels and 6-month mortality rate (r = 0.35; 95%CI: 0.05-0.60; p = 0.02), as well as previous cardiac resynchronization therapy (CRT) and preoperative CRP levels (r = -0.37; 95%CI: -0.61--0.07, p = 0.01) were highlighted. A value for CRP > 1.66 mg/dL was found to be associated with 6-month mortality (OR = 18.00; 95%CI: 1.90-170.33, p < 0.01). Moreover, the patients who received CRT before transplantation had significantly lower levels of CRP when compared to those who did not receive CRT (p = 0.01). Conclusions: Preoperative CRP levels could represent a valuable asset in the follow-up algorithm of heart transplant patients. The lower levels of CRP in patients who benefited from CRT before transplantation highlights the importance of understanding the complex mechanisms of inflammation and increasing focus on device therapy for future transplant recipients. Further prospective studies with larger cohorts are needed for validation.

Keywords: 6-month mortality; C-reactive protein; cardiac resynchronization therapy; heart transplant; inflammation.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Inclusion criteria. BMI: body mass index; BSA: body surface area; CRP: C-reactive protein; CRT: cardiac resynchronization therapy; ICU: intensive care unit.
Figure 2
Figure 2
Statistical analysis premise. CRP: C-reactive protein; ROC: receiver operating characteristic.
Figure 3
Figure 3
ROC curve for CRP and 6-month mortality. ROC: receiver operating characteristic. CRP: C-reactive protein.
See this image and copyright information in PMC

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