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. 2024;19(3):300-305.
doi: 10.30699/IJP.2024.2017566.3225. Epub 2024 Jul 24.

Prospective Analytical Case-Control Study of COVID-19 Positive Versus Negative Patients for Subclinical Placental Dysfunction

Poojan Dogra Marwaha  1 , Jyoti Bala  2 , Suchi Sharma  2 , Asmita Kaundal  1 , Neha Chauhan  3
Affiliations

Prospective Analytical Case-Control Study of COVID-19 Positive Versus Negative Patients for Subclinical Placental Dysfunction

Poojan Dogra Marwaha et al. Iran J Pathol. 2024.

Abstract

Background & objective: Placenta provides nutrition and protection from various infections and toxins to the baby while they are in the mother's womb. The present study was done to see the effects of coronavirus infection on the placenta of infected mothers and the final pregnancy outcome.

Methods: A total of 50 antenatal women (25 infected with coronavirus and 25 uninfected women) were enrolled and their placentae were examined for any significant histopathological changes. These changes were then correlated with the final pregnancy outcome.

Results: A significant number of placentae from infected mothers demonstrated features of maternal (54%) and fetal malperfusion (76%). However, no significant adverse pregnancy outcome was noted.

Conclusion: Increased rates of maternal malperfusion, and fetal malperfusion may be seen in placentae from infected women. However, these changes may not progress to any adverse fetal outcomes.

Keywords: COVID-19; Pathology; Placenta; Pregnancy.

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Conflict of interest statement

There is no conflict of interest among the authors.

References

    1. Abedzadeh‐Kalahroudi M, Sehat M, Vahedpour Z, Talebian P. Maternal and neonatal outcomes of pregnant patients with COVID-19: A prospective cohort study. Int J Gynaecol Obstet. 2021 ;153(3):449–56. - PMC - PubMed
    1. Knight M, Bunch K, Vousden N, Morris E, Simpson N, Gale C, et al. UK Obstetric Surveillance System SARS-CoV-2 Infection in Pregnancy Collaborative Group Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study. BMJ. 2020;369:m2107. - PMC - PubMed
    1. Walker KF, O'Donoghue K, Grace N, Dorling J, Comeau JL, Li W, et al. Maternal transmission of SARS-COV-2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis. BJOG. 2020 Oct;127(11):1324–36. - PMC - PubMed
    1. Hoo R, Nakimuli A, Vento-Tormo R. Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface. Front Immunol. 2020 ;11:2070. - PMC - PubMed
    1. Ptacek I, Sebire NJ, Man JA, Brownbill P, Heazell AE. Systematic review of placental pathology reported in association with stillbirth. Placenta. 2014 ;35(8):552–62. - PubMed

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