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Case Reports
. 2024 Nov 15;16(11):e73735.
doi: 10.7759/cureus.73735. eCollection 2024 Nov.

Upper Extremity Dedifferentiated Liposarcoma With an Osseus Component: An Uncommon Pathology

Emmanuel Ihionkhan  1 , Vincent Marcucci  2 , Victoria Grille  2 , Peter Alexander  3 , John Gibbs  2
Affiliations
Case Reports

Upper Extremity Dedifferentiated Liposarcoma With an Osseus Component: An Uncommon Pathology

Emmanuel Ihionkhan et al. Cureus. .

Abstract

Liposarcomas are the most common soft tissue sarcoma primarily originating in deep soft tissues and the retroperitoneum. Sarcoma classification includes atypical lipomatous tumor/well-differentiated liposarcoma (WDL) and dedifferentiated liposarcoma (DDL), myxoid liposarcoma, and pleomorphic liposarcoma. DDL is most prevalent in the retroperitoneum and often has two distinct components, a well-differentiated lipomatous component and a dedifferentiated nonlipomatous component that could be morphologically similar to malignant fibrous histiocytoma (MFH) or fibrosarcoma. DDLs can undergo heterologous differentiation into multiple cancer types including rhabdomyosarcoma, chondrosarcoma, melanoma, and leiomyosarcoma. Rarely, DDLs can undergo metaplastic bone formation. We report a peculiar case of a DDL with an osseous component.

Keywords: basic oncology; histochemisty; orthopedic; sarcoma; surgery.

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Conflict of interest statement

Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. T2 weighted MRI image of right upper extremity showing a heterogeneous soft tissue with bone abutment (blue arrow)
Figure 2
Figure 2. Coronal view of CT chest showing no signs of metastatic disease.
Figure 3
Figure 3. Gross image of the dedifferentiated liposarcoma.
Figure 4
Figure 4. Wound bed status post tumor resection with the median nerve visible (blue arrow).
See this image and copyright information in PMC

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