Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Nov 15;10(23):e40456.
doi: 10.1016/j.heliyon.2024.e40456. eCollection 2024 Dec 15.

Association between Clinical Frailty Scale and mortality 24 months after hospitalisation in adult patients with COVID-19

Julia Minnema  1   2 , Melvin Lafeber  1 , Roos S G Sablerolles  2 , Janneke A L van Kempen  3 , Lisanne Tap  1 , Harmke A Polinder-Bos  1 , Bob P A van de Loo  4 , Hugo van der Kuy  2 , Miriam C Faes  3 ; COMET-, and COOP-research group
Collaborators, Affiliations

Association between Clinical Frailty Scale and mortality 24 months after hospitalisation in adult patients with COVID-19

Julia Minnema et al. Heliyon. .

Abstract

Background: The clinical frailty scale (CFS) was used as a triage tool for medical decision making during the COVID-19 pandemic. The CFS has been posed as a suitable risk marker for in-hospital mortality in COVID-19 patients. We evaluated whether the CFS is associated with mortality 24 months after hospitalisation for COVID-19.

Methods: The COvid MEdicaTion (COMET) study is an international, multicentre, observational cohort study, including adult patients hospitalised for COVID-19 between March 2020-July 2020. Patients' characteristics, prescribed medication, clinical characteristics, and CFS were collected at admission, survival data were collected 24 months after hospitalisation. Multivariable cox proportional hazard models stratified by age (<65 and ≥65 years), and adjusted for covariates (age, sex, number of drugs, and types of drug class as a proxy for comorbidities) were used to study the association between the CFS and 24-month mortality after hospitalisation.

Results: In this study, 1238 fit (CFS 1-3), 478 mildly frail (CFS 4-5), and 235 frail (CFS 6-9) patients were included for baseline analysis (median age 68 years (IQR 58-78); 58.5 % male). Frailty was associated with an increased risk of 24-month mortality after hospitalisation in older patients (HR 1.91, 95 % CI [1.17-3.12]), in younger adults a trend was seen (HR 3.13, 95 % CI [0.86-11.36]).

Conclusion: The results suggest that the CFS is an indicator for mortality 24 months after hospitalisation in COVID-19 patients.

Keywords: COVID-19; Frailty; Long-term; Survival.

PubMed Disclaimer

Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Hugo van der Kuy reports financial support was provided by 10.13039/501100001826Netherlands Organisation for Health Research and Development. Hugo van der Kuy reports financial support was provided by LOEY Foundation. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
24-months mortality after hospital discharge for patients <65 years of age (excluding in-hospital mortality) (n = 800).
Fig. 2
Fig. 2
24-months mortality after hospital discharge for patients ≥65 years of age (excluding in-hospital mortality) (n = 1085).
See this image and copyright information in PMC

References

    1. Derde L., Schouten J., Wittekamp B. Maart 2021. Draaiboek pandemie deel 1 Nederlandse Vereniging voor Intensive Care (NVIC) Draaiboek pandemie deel 1.pdf (demedischspecialist.nl)
    1. National Institute for H., Care E. NICE Guideline; 2021. COVID-19 Rapid Guideline: Managing COVID-19. NG191. - PubMed
    1. Rockwood K., Theou O. Using the clinical frailty scale in allocating scarce health care resources. Can. Geriatr. J. 2020;23(3):210. - PMC - PubMed
    1. Clegg A., et al. Frailty in elderly people. Lancet. 2013;381(9868):752–762. - PMC - PubMed
    1. Church S., et al. A scoping review of the clinical frailty scale. BMC Geriatr. 2020;20(1):1–18. - PMC - PubMed

LinkOut - more resources