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. 2026 Jan 1;21(1):320-321.
doi: 10.4103/NRR.NRR-D-24-01156. Epub 2024 Dec 16.

Alpha-synuclein-induced upregulation of SKI family transcriptional corepressor 1: A new player in aging and Parkinson's disease?

Lauren Barrett  1 , Rebekah Bevans  1 , Aideen M Sullivan  2 , Louise M Collins  1 , Gerard W O'Keeffe  1
Affiliations

Alpha-synuclein-induced upregulation of SKI family transcriptional corepressor 1: A new player in aging and Parkinson's disease?

Lauren Barrett et al. Neural Regen Res. .
No abstract available

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Figures

Figure 1
Figure 1
SKOR1 is endogenously expressed in SH-SY5Y cells and SKOR1 overexpression impairs neurite growth. (A) Representative photomicrographs of SH-SY5Y cells at 72 hours in vitro, immunocytochemically stained for Skor1 (green) and DAPI (blue), showing that Skor1 is endogenously expressed in both the cytoplasm (red arrows) and nucleus (white arrows) of SH-SY5Y cells. (B) Representative photomicrographs of SH-SY5Y cells at 72 hours post-transfection with 500 ng of a plasmid expressing either FLAG or FLAG-tagged Skor1 plus GFP to visualize transfected cells. SKOR1 overexpression significantly reduced neurite growth. Unpublished data. DAPI: 4′,6-Diamidino-2-phenylindole; GFP: green fluorescent protein; SKOR1: SKI family transcriptional corepressor 1.
See this image and copyright information in PMC

References

    1. Arndt S, Poser I, Moser M, Bosserhoff AK. Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling. Mol Cell Neurosci. 2007;34:603–611. - PubMed
    1. Fischer S, Bayersdorfer F, Harant E, Reng R, Arndt S, Bosserhoff AK, Schneuwly S. fussel (fuss) - a negative regulator of BMP signaling in Drosophila melanogaster. PLoS One. 2012;7:e42349. - PMC - PubMed
    1. Gan-Or Z, Alcalay RN, Bar-Shira A, Leblond CS, Postuma RB, Ben-Shachar S, Waters C, Johnson A, Levy O, Mirelman A, Gana-Weisz M, Dupré N, Montplaisir J, Giladi N, Fahn S, Xiong L, Dion PA, Orr-Urtreger A, Rouleau GA. Genetic markers of restless legs syndrome in Parkinson disease. Parkinsonism Relat Disord. 2015;21:582–585. - PMC - PubMed
    1. Goulding SR, Concannon RM, Morales-Prieto N, Villalobos-Manriquez F, Clarke G, Collins LM, Lévesque M, Wyatt SL, Sullivan AM, O’Keeffe GW. Growth differentiation factor 5 exerts neuroprotection in an α-synuclein rat model of Parkinson’s disease. Brain. 2021;144:e14. - PubMed
    1. Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Agúndez JAG. Genetics of restless legs syndrome: an update. Sleep Med Rev. 2018;39:108–121. - PubMed

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