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. 2024 Dec 17;163(1):17.
doi: 10.1007/s00418-024-02344-3.

Effect of middle-age plasma therapy on ileum morphology, immune defense (IgA) and cell proliferation (Ki-67) of female aged rats

Ender Deniz Asmaz  1 , Hikmet Taner Teker  2 , Zeynep Tuğçe Sertkaya  3 , Taha Ceylani  4 , Aysun İnan Genç  5
Affiliations

Effect of middle-age plasma therapy on ileum morphology, immune defense (IgA) and cell proliferation (Ki-67) of female aged rats

Ender Deniz Asmaz et al. Histochem Cell Biol. .

Abstract

Blood plasma therapy, a new treatment method to eliminate the damage and deterioration caused by aging in many organ systems, has attracted increasing attention. The digestive tract, which cooperates with many different systems, has strong effects on our health. In the present study, the effects of plasma therapy on the ileum of elderly rats were investigated. Wistar rats (n = 7; 12-15 months old) were given pooled plasma collected from middle-age rats (6 months, n =28) (for 30 days, 0.3 ml daily, intravenously into the tail vein). At the end of the experiment, villus height, crypt depth, total mucosal thickness and surface absorption area were evaluated. In addition, the effects of IgA, which plays a role in the digestive system's defense against microorganisms, were examined. Both the cell proliferation intensity and proliferation index were evaluated in crypt cells. An increase was determined in all morphological parameters in the experimental group. Similarly, plasma application decreased IgA expression and numbers in the experimental groups. Contrarily, cell proliferation parameters showed a significant increase in the experimental groups' crypt cells. Therefore, we found that the treatment supports the digestive system in terms of both nutrient utilization and absorption-related parameters and has a protective effect on intestinal immune system parameters.

Keywords: Blood plasma treatment; IgA; Ileum; Ki-67; Wistar rat.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests. The authors have no conflicts of interest to declare.

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