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Editorial
. 2025 Jan;17(1):1-3.
doi: 10.1080/1750743X.2024.2442899. Epub 2024 Dec 18.

How could histotripsy change cancer immunotherapy?

Heineken Queen  1 , Clifford S Cho  2   3
Affiliations
Editorial

How could histotripsy change cancer immunotherapy?

Heineken Queen et al. Immunotherapy. 2025 Jan.
No abstract available

Keywords: Histotripsy; T cell; abscopal; cancer; immunology; immunotherapy; ultrasound.

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Conflict of interest statement

CSC has intellectual property related to the immune effects of histotripsy. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

References

    1. Xu Z, Khokhlova TD, Cho CS, et al. Histotripsy: a method for mechanical tissue ablation with ultrasound. Annu Rev Biomed Eng. 2024;16(1):141–167. doi: 10.1146/annurev-bioeng-073123-022334 - DOI - PMC - PubMed
    1. Mendiratta-Lala M, Wiggermann P, Pech M, et al. The #HOPE4LIVER single-arm pivotal trial for histotripsy of primary and metastatic liver tumors. Radiology. 2024;312(3):e233051. doi: 10.1148/radiol.233051 - DOI - PMC - PubMed

    2. •• The demonstration of short-term efficacy and safety in this multicenter clinical trial helped lead to FDA clearance of histotripsy for the treatment of primary and metastatic liver tumors

    1. Legrand AJ, Konstantinou M, Goode EF, et al. The diversification of cell death and immunity: memento mori. Mol Cell. 2019;76(2):232–242. doi: 10.1016/j.molcel.2019.09.006 - DOI - PubMed
    1. Qu S, Worlikar T, Felsted AE, et al. Non-thermal histotripsy tumor ablation promotes abscopal immune responses that enhance cancer immunotherapy. J Immunother Cancer. 2020;8(1):e000200. doi: 10.1136/jitc-2019-000200 - DOI - PMC - PubMed

    2. •• In immunocompetent murine models, histotripsy tumor treatment triggered local and abscopal anti-tumor immune responses capable of enhancing the effects of checkpoint inhibition immunotherapy

    1. Thim EA, Kitelinger LE, Rivera-Escalera F, et al. Focused ultrasound ablation of melanoma with boiling histotripsy yields abscopal tumor control and antigen-dependent dendritic cell activation. Theranostics. 2024;14(4):1647–1661. doi: 10.7150/thno.92089 - DOI - PMC - PubMed

    2. •• An immunocompetent murine melanoma model was used to demonstrate that boiling histotripsy triggered innate immune cell presentation of tumor antigen

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