Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Dec 17;14(53):39636-39644.
doi: 10.1039/d4ra07857h. eCollection 2024 Dec 10.

TiO2/CuWO4 heterojunction photocatalyst in the preparation of cardiovascular chromeno[4,3- b]chromene drugs

Jiaqi Sun  1 , Jiahao Song  1
Affiliations

TiO2/CuWO4 heterojunction photocatalyst in the preparation of cardiovascular chromeno[4,3- b]chromene drugs

Jiaqi Sun et al. RSC Adv. .

Abstract

Chromeno[4,3-b]chromenes have shown potential as effective drugs against cardiovascular diseases. This study centered on a novel heterojunction nanocomposite TiO2/CuWO4, which incorporates titanium dioxide (TiO2) and copper tungstate(vi) to improve photocatalytic efficiency. The characterization of the TiO2/CuWO4 photocatalyst was performed using various techniques, including FT-IR, XRD, TEM, DRS, SEM, EDS, and XPS. TiO2/CuWO4 demonstrated significant effectiveness as a photocatalyst for the synthesis of chromeno[4,3-b]chromene derivatives, which show potential antibacterial and antifungal properties beneficial for oral health concerns such as dental caries and periodontal disease. While TiO2 can absorb light to produce electrons and holes under direct illumination, its photocatalytic efficiency is improved when paired with CuWO4. The research also explored the influence of several factors, including the quantity of photocatalyst, reaction duration, temperature, solvent selection, and the reusability of the nanocomposite. Optimal reaction conditions were found to involve 1 mmol of dimedone, benzaldehyde, and 4-hydroxycoumarin, using 12 mg of TiO2/CuWO4 in 4 mL of ethanol, subjected to irradiation from a green laser at room temperature for 30 minutes. The results indicate that the TiO2/CuWO4 heterojunction ranks among the most effective options for photocatalytic synthesis of chromeno[4,3-b]chromene derivatives.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts to declare.

Figures

Fig. 1
Fig. 1. Production of various substituted chromeno[4,3b]chromenes.
Fig. 2
Fig. 2. FE-SEM images of (a) TiO2 and (b) TiO2/CuWO4. (c) TEM image of TiO2/CuWO4.
Fig. 3
Fig. 3. EDX pattern of TiO2/CuWO4.
Fig. 4
Fig. 4. FT-IR of TiO2/CuWO4, CuWO4, and TiO2.
Fig. 5
Fig. 5. XRD of TiO2/CuWO4.
Fig. 6
Fig. 6. UV-Vis spectrum of TiO2/CuWO4; the Tauc plots for TiO2 (a), CuWO4 (b), and TiO2/CuWO4 (c).
Fig. 7
Fig. 7. Effect of photocatalyst on the yield of chromeno[4,3-b]chromene.
Fig. 8
Fig. 8. Effect of reaction time.
Fig. 9
Fig. 9. Photocatalytic activity of some related photocatalysts in the condensation reaction.
Fig. 10
Fig. 10. Effects of reaction temperature.
Fig. 11
Fig. 11. Effect of different solvents.
Fig. 12
Fig. 12. SEM images of (a) reused and (b) fresh TiO2/CuWO4.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Benny A. T. Arikkatt S. D. Vazhappilly C. G. Kannadasan S. Thomas R. Leelabaiamma M. S. Radhakrishnan E. K. Shanmugam P. Chromone, a privileged scaffold in drug discovery: developments in the synthesis and bioactivity. Mini-Rev. Med. Chem. 2022;22(7):1030–1063. - PubMed
    1. Jadhaw B. Gandhi B. Jhansi M. Misra S. Kaki S. S. Synthesis and Biological Evaluation of Novel Lipophilic Chromene Based 1,3,4-Oxadiazoles for Anti-cancer and Anti-inflammatory Activity. Arabian J. Sci. Eng. 2024;49(1):221–230.
    1. Dawood D. H. Srour A. M. Saleh D. O. Huff K. J. Greco F. Osborn H. M. New pyridine and chromene scaffolds as potent vasorelaxant and anticancer agents. RSC Adv. 2021;11(47):29441–29452. - PMC - PubMed
    1. Zhang Y. Jiang R. Lei L. Yang Y. Hu T. Drug delivery systems for oral disease applications. J. Appl. Oral Sci. 2022;30:e20210349. - PMC - PubMed
    1. Kushwaha R. K. Singh K. Kumar P. Chandra D. Review on Chromen Derivatives and Their Pharmacological Activities. Res. J. Pharm. Technol. 2019;12(11):5566–5574.

LinkOut - more resources