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Editorial
. 2024 Dec 3:12:1522963.
doi: 10.3389/fped.2024.1522963. eCollection 2024.

Editorial: Optimizing outcomes for children with immune-mediated chronic kidney disease

Thomas Renson  1   2 , Evelien Snauwaert  3   4 , Lorraine Hamiwka  5   6 , Susa Benseler  7 , Lovro Lamot  8   9
Affiliations
Editorial

Editorial: Optimizing outcomes for children with immune-mediated chronic kidney disease

Thomas Renson et al. Front Pediatr. .
No abstract available

Keywords: CKD—chronic kidney disease; glomerular disease; immune-mediated; kidney disease; pediatrics.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Figures

Figure 1
Figure 1
Key mechanisms of immune dysregulation leading to chronic kidney disease (CKD) (4). Immune-mediated kidney inflammation can be caused by direct (e.g., autoantibodies targeting renal antigens) or indirect (e.g., immune complex formation, complement activation, neutrophil extracellular trap formation) pathways. In both mechanisms, kidney inflammation subsequently leads to a loss of immune homeostasis, which facilitates further damage and the development of CKD. An uncoordinated tissue repair leads to fibrosis which compromises immune homeostasis. NETs = neutrophil extracellular traps; MAC = membrane attack complex (initiated by complement pathway activation).
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  • Editorial on the Research Topic Optimizing outcomes for children with immune-mediated chronic kidney disease

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