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. 2025 Feb 1;16(2):e00804.
doi: 10.14309/ctg.0000000000000804.

Multidisciplinary Approach Improves Eradication Rate and Safety in Refractory Helicobacter pylori Infection

Na Dai  1 , Yu-Qin Zhao  2 , Wen-Juan Wu  1 , Zheng-Lin Shen  2 , Yan-Hua Xu  1 , Xiao-Yang Wu  3 , Gui-Zhen Zhang  1 , Lan Wang  1 , Qing-Hua Wang  1
Affiliations

Multidisciplinary Approach Improves Eradication Rate and Safety in Refractory Helicobacter pylori Infection

Na Dai et al. Clin Transl Gastroenterol. .

Abstract

Introduction: Helicobacter pylori (HP) infection is prevalent worldwide and contributes to various gastrointestinal diseases. Eradication therapy is crucial in managing HP infection, but antibiotic resistance has led to refractory cases, complicating treatment outcomes and increasing the risk of adverse events. This study aimed to evaluate the effectiveness of a multidisciplinary approach, termed HP Multidisciplinary Team (MDT) Clinic, in improving eradication rates and safety in patients with refractory HP infection.

Methods: Between November 2020 and November 2023, 153 patients with refractory HP infection were included, with 51 patients in the non-HP-MDT group and 102 patients in the HP-MDT group. The HP-MDT clinic provided personalized treatment plans, patient education, and follow-up. Genetic testing was conducted in selected cases to assess resistance patterns.

Results: Patients attending the HP-MDT clinic showed significantly higher eradication rates compared with those in the non-HP-MDT group (80.39% vs 50.98%, P < 0.001). Logistic regression analysis confirmed that HP-MDT clinic attendance was independently associated with higher eradication rates (odds ratio: 4.43, 95% CI: 2.02 to 9.71, P < 0.001). Genetic testing revealed high rates of antibiotic resistance, particularly to clarithromycin (10/11, 90.91%) and metronidazole (11/11, 100%). Despite resistance, the HP-MDT approach achieved a high eradication rate of 92.31%. Adverse drug reactions occurred in 12.75% of patients in the HP-MDT group, predominantly mild gastrointestinal symptoms.

Discussion: The HP-MDT clinic, integrating medical, pharmaceutical, and nursing expertise, significantly improved eradication rates and safety in patients with refractory HP infection. Personalized treatment plans, patient education, and genetic testing contributed to successful outcomes with minimal adverse events.

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Conflict of interest statement

Guarantor of the article: Yu-Qin Zhao, MM.

Specific author contributions: We declare that all the listed authors have participated actively in the study, and all meet the requirements of the authorship. Drs. Y.Q.Z. designed the study and wrote the protocol, Drs. N.D., W.J.W., Z.L.S., and Y.H.X. acquired the manuscript, Drs. N.D., X.Y. W., G.Z.Z., L.W., and Q.H.W. analyzed the data, Drs. N.D. and Y.Q.Z. wrote the first draft of the manuscript and mainly revised the manuscript. All authors approved the final version of the manuscript.

Financial support: This study was supported by the Science and Technology Plan Project of The First People's Hospital of Kunshan in 2021 (No. KRY- YN001) and 2021 Kunshan Municipal Science and Technology Special Project (Health) (No. KSZ2159).

Potential competing interests: None to report.

IRB approval statement: This study was approved by the independent Ethics Committee at the First People's Hospital of Kunshan (No. EC-SOP-007-A07-V4.0). Written informed consent was waived by the IRB due to the retrospective nature of this study.

Figures

None
Graphical abstract
Figure 1.
Figure 1.
Patient treatment pathway flowchart. HP, Helicobacter pylori; MDT, Multidisciplinary Team.
Figure 2.
Figure 2.
The eradication rates stratified by independent variables, including (a) outpatient clinic, (b) sex, (c) age, and (d) treatment session group. HP, Helicobacter pylori; MDT, Multidisciplinary Team.
See this image and copyright information in PMC

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References

    1. Ali A, AlHussaini KI. Helicobacter pylori: A contemporary perspective on pathogenesis, diagnosis and treatment strategies. Microorganisms 2024;12(1):222. - PMC - PubMed
    1. Li Y, Choi H, Leung K, et al. Global prevalence of Helicobacter pylori infection between 1980 and 2022: A systematic review and meta-analysis. Lancet Gastroenterol Hepatol 2023;8(6):553–64. - PubMed
    1. Tsay FW, Hsu PI. H. pylori infection and extra-gastroduodenal diseases. J Biomed Sci. 2018;25(1):65. - PMC - PubMed
    1. Piscione M, Mazzone M, Di Marcantonio MC, et al. Eradication of Helicobacter pylori and gastric cancer: A controversial relationship. Front Microbiol 2021;12:630852. - PMC - PubMed
    1. Kamada T, Satoh K, Itoh T, et al. Evidence-based clinical practice guidelines for peptic ulcer disease 2020. J Gastroenterol 2021;56(4):303–22. - PMC - PubMed

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