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. 2024 Dec 31;58(52):22843-22864.
doi: 10.1021/acs.est.3c09524. Epub 2024 Dec 18.

Effects of Microplastic Exposure on Human Digestive, Reproductive, and Respiratory Health: A Rapid Systematic Review

Nicholas Chartres  1   2 , Courtney B Cooper  1 , Garret Bland  1 , Katherine E Pelch  3 , Sheiphali A Gandhi  4   5 , Abena BakenRa  1 , Tracey J Woodruff  1
Affiliations

Effects of Microplastic Exposure on Human Digestive, Reproductive, and Respiratory Health: A Rapid Systematic Review

Nicholas Chartres et al. Environ Sci Technol. .

Abstract

Microplastics are ubiquitous environmental contaminants for which there are documented human exposures, but there is a paucity of research evaluating their impacts on human health. We conducted a rapid systematic review using the "Navigation Guide" systematic review method. We searched four databases in July 2022 and April 2024 with no restriction on the date. We included studies using predefined eligibility criteria that quantitatively examined the association of microplastic exposure with any health outcomes. We amended the eligibility criteria after screening studies and prioritized digestive, reproductive, and respiratory outcomes for further evaluation. We included three human observational studies examining reproductive (n = 2) and respiratory (n = 1) outcomes and 28 animal studies examining reproductive (n = 11), respiratory (n = 7), and digestive (n = 10) outcomes. For reproductive outcomes (sperm quality) and digestive outcomes (immunosuppresion) we rated overall body evidence as "high" quality and concluded microplastic exposure is "suspected" to adversely impact them. For reproductive outcomes (female follicles and reproductive hormones), digestive outcomes (gross or microanatomic colon/small intestine effects, alters cell proliferation and cell death, and chronic inflammation), and respiratory outcomes (pulmonary function, lung injury, chronic inflammation, and oxidative stress) we rated the overall body of evidence as "moderate" quality and concluded microplastic exposure is "suspected" to adversely impact them. We concluded that exposure to microplastics is "unclassifiable" for birth outcomes and gestational age in humans on the basis of the "low" and "very low" quality of the evidence. We concluded that microplastics are "suspected" to harm human reproductive, digestive, and respiratory health, with a suggested link to colon and lung cancer. Future research on microplastics should investigate additional health outcomes impacted by microplastic exposure and identify strategies to reduce exposure.

Keywords: cancer; digestive; hazard assessment; microplastics; reproductive; respiratory; systematic review; toxicology.

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Conflict of interest statement

The authors declare no competing financial interest.

Figures

Figure 1
Figure 1
Evaluating the quality and strength of the body of evidence using Navigation Guide.
Figure 2
Figure 2
Hazard identification conclusion statements informed by the NTP OHAT approach.
Figure 3
Figure 3
Apical outcomes (colon and small intestine).
See this image and copyright information in PMC

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